Testosterone & Insulin Sensitivity / Glucose Metabolism (Human Evidence).
1. Established associations in humans:
· Low testosterone levels are strongly
associated with insulin resistance and increased diabetes risk in men. Clinical
studies show men with lower testosterone tend to have poorer insulin
sensitivity.
PubMed https://pubmed.ncbi.nlm.nih.gov/40771640/
· A clinical crossover study in
hypogonadal men with type 2 diabetes showed that testosterone treatment
improved insulin sensitivity, fasting glucose, and HbA1c (a long-term blood
sugar marker).
PubMed https://pubmed.ncbi.nlm.nih.gov/16728551/
·
Additional
trials and meta-analyses report modest improvements in insulin resistance
measures with testosterone therapy in metabolic syndrome contexts, though
effects on glucose outcomes can vary by study and population.
Healthy
Male.
· 📌 Interpretation:
This body of clinical evidence
confirms that hormonal improvements (higher testosterone) tend to correlate
with better insulin action and some aspects of glucose metabolism in men with
low testosterone or metabolic disorders (e.g., metabolic syndrome, type 2
diabetes or hypogonadism).
PubMed +1 https://pubmed.ncbi.nlm.nih.gov/16728551/
2.
Tongkat
Ali (Eurycoma longifolia) & Testosterone (Clinical Evidence)
✅ Clinically confirmed:
A systematic review and
meta-analysis of human randomized clinical trials shows that Eurycoma
longifolia supplementation significantly increases total testosterone levels in
men - both healthy individuals and those with low testosterone.
PubMed https://pubmed.ncbi.nlm.nih.gov/36013514/
· Several independent clinical studies
also show increased testosterone or total androgen levels after
supplementation.
PMC
https://pmc.ncbi.nlm.nih.gov/articles/PMC9415500/?utm_source=chatgpt.com
· 📌 Interpretation:
The evidence supports that
high-quality Tongkat Ali extract can raise serum testosterone in humans in
controlled settings, making it a scientifically supported herbal testosterone
booster.
PubMed https://pubmed.ncbi.nlm.nih.gov/36013514/
3.
Tongkat
Ali & Glucose / Insulin Pathways (Mechanistic / Preclinical Evidence)
· Preclinical laboratory and animal
evidence:
Some research (animal studies) shows
that Tongkat Ali extracts exhibited antihyperglycemic effects, including
improved glucose tolerance and increased insulin secretion in diabetic animal
models.
· In vitro studies have shown that
Tongkat Ali extracts can enhance insulin secretion from pancreatic cells and
increase glucose uptake into cells in lab models.
ResearchGate
· Reviews of pharmacology note
glucose-related effects in cell or animal studies, including enhanced glucose
uptake and improved insulin signaling pathways.
MDPI https://www.mdpi.com/1420-3049/21/3/331?utm_source=chatgpt.com
· 📌 Important Clarification:
➡️ Human clinical evidence for Tongkat Ali
directly improving blood sugar or insulin sensitivity in people is limited or
absent so far.
➡️ The supportive evidence currently comes from
animal models and lab mechanisms, not definitive human clinical trials.
➡️ Therefore any statements that Tongkat Ali
directly lowers blood sugar in people should be clearly qualified as
preclinical evidence, promising but not yet proven in humans.
PMC +1 https://pmc.ncbi.nlm.nih.gov/articles/PMC9415500/?utm_source=chatgpt.com
4.
What
This Means for Messaging & Positioning
Supported by human clinical evidence:
· ✅Tongkat Ali increases testosterone levels in
men (RCTs + meta-analysis).
PubMed https://pubmed.ncbi.nlm.nih.gov/36013514/
· ✅Higher testosterone in men is generally
associated with better insulin sensitivity and improved aspects of glucose
metabolism.
PubMed https://pubmed.ncbi.nlm.nih.gov/40771640/
Mechanistic / preclinical only (not yet
clinical in humans):
· Tongkat Ali’s effects on insulin secretion,
glucose uptake, and direct blood sugar lowering mainly shown in animals and in
vitro studies.
· 📌 Appropriate scientific nuance for claims:
i.
Tongkat
Ali has strong clinical evidence for increasing testosterone. PubMed https://pubmed.ncbi.nlm.nih.gov/36013514/
ii.
Higher
testosterone is linked to improved metabolic pathways including insulin
sensitivity. PubMed https://pubmed.ncbi.nlm.nih.gov/40771640/
iii.
Preclinical
studies suggest possible glucose regulatory pathways for Tongkat Ali, which
make it a promising subject for future human studies. ResearchGate
Summary
Table ✅
|
Topic |
Human Clinical Evidence |
Preclinic Support |
|
Testosterone ↑ with Tongkat Ali |
Yes - Meta-analysis & RCTs PubMed https://pubmed.ncbi.nlm.nih.gov/36013514/
|
NON - |
|
Testosterone improving insulin
sensitivity |
Yes - in clinical hormone therapy
contexts |
NON - |
|
Tongkat Ali improving glucose
control in people |
No direct human clinical trials
yet |
Yes - animal & in vitro
studies ResearchGate https://www.researchgate.net/publication/342995332_ |
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