Energy Is the First Medicine: How Clinically Studied Tongkat Ali May Support Stroke Recovery and Brain Repair.

Nu-Prep

Scientifically grounded explanation of how Nu-Prep’s active ingredient (standardized water-soluble - freeze dried extract of Tongkat Ali) may support stroke patients, daily energy needs & brain recovery processes including neuroplasticity & BDNF-like effects.

·       A Journey from the Rainforest to the Recovering Brain.

Imagine a stroke survivor a once-active soul who now wakes every morning with a heavy weight: lack of energy, brain fog, fatigue, emotional imbalance, slow cognition, and a long road of rehabilitation ahead. This is where Nu-Prep’s active ingredient, a standardized water-soluble freeze-dried extract of Eurycoma longifolia (Tongkat Ali) steps into the story, offering potential support based on clinical and preclinical science.

 

A Powerful Herbal Root: The Science Behind Tongkat Ali

1.      Traditional Uses Meet Modern Science.

Tongkat Ali, known as Malaysian Ginseng, has been used for centuries in traditional medicine for vitality, strength, mood, and resilience. Modern research has translated these traditional uses into clinical evidence showing meaningful effects on stress hormones, energy, mood, and physical function.

https://pubmed.ncbi.nlm.nih.gov/23705671/  

 

A standardized water-soluble or freeze-dried extract (such as Physta® used in research) is critical not all extracts are equal. Only properly standardized extracts, rich in bioactive components like eurycomanone, eurypeptides, glycosaponins, and proteins, have demonstrated consistency in clinical settings.

https://akarali.com/physta-tongkat-ali/?utm_source=chatgpt.com

 

From Stress Hormones to Daily Energy & Mood

→ Improving the Cortisol-Testosterone Balance

Chronic stress and elevated cortisol levels can drain energy, worsen mood & slow physical recovery.  

https://pubmed.ncbi.nlm.nih.gov/23705671/

Studies show Tongkat Ali supplementation significantly reduces cortisol & increases testosterone status in adults, supporting a better hormonal balance. https://pubmed.ncbi.nlm.nih.gov/23705671/

→ What This Means for Energy & Rehabilitation

For a stroke patient:

·       Higher energy levels. With cortisol reduced & metabolic balance improved, the body conserves energy better, making each day’s rehab exercises more sustainable.

·       Improved mood & mental clarity. Less tension, anger, confusion; more motivation to engage with therapy & daily tasks.

https://pmc.ncbi.nlm.nih.gov/articles/PMC3669033/?utm_source=chatgpt.com  

 

·       Physical Functioning. Clinical trials show better physical functioning scores with consistent extract use, which aligns with enhanced daily activity levels. https://akarali.com/physta-clinical-studies/?utm_source=chatgpt.com

 

A stroke survivor who wakes with more physical ease, sharper focus & emotional balance is more likely to do more from taking a walk to pushing further in physical therapy.

 

How This Connects to the Brain: Neuroplasticity & BDNF.

While no direct clinical study has shown that Tongkat Ali extract boosts BDNF directly in humans, here’s the bridge between what we do know scientifically & why it matters:

 

What BDNF Does

Brain-Derived Neurotrophic Factor (BDNF) is a critical brain protein that:

·       Helps neurons survive, grow & form new connections

·       Supports neuroplasticity the ability of the brain to rewire itself after injury

·       Enhances memory, cognition & emotional resilience all vital for recovery after stroke. https://pmc.ncbi.nlm.nih.gov/articles/PMC7204205/?utm_source=chatgpt.com

 

Why Supporting Neuroplasticity Matters After Stroke.

Stroke damages brain networks. Successful recovery depends on the brain’s ability to reroute functions & rebuild connections. BDNF is one of the key drivers of this healing process, guiding neurons to reconnect and form new pathways.

https://pmc.ncbi.nlm.nih.gov/articles/PMC7204205/?utm_source=chatgpt.com

 

How Tongkat Ali May Indirectly Support BDNF-Like Brain Health

1.      Reducing Stress That Inhibits Neuroplasticity,

High cortisol suppresses BDNF expression & limits neuroplasticity. By lowering cortisol & improving mood, Tongkat Ali may remove a major brake on the brain’s healing processes. https://pubmed.ncbi.nlm.nih.gov/23705671/

 

2.      Improving Dopamine & Neurotransmitter Balance

Some studies & mechanistic research show Tongkat Ali extract can increase cortical & hippocampal dopamine a neurotransmitter important for motivation, learning & memory.

https://akarali.com/tongkat-ali-effects-dopamine/?utm_source=chatgpt.com

 

Having balanced dopamine supports brain function & can create an internal brain environment more receptive to rehabilitation & learning new neural pathways.

 

3.      Antioxidant & Anti-Inflammatory Properties

Preclinical evidence suggests Tongkat Ali may have antioxidant & anti-inflammatory effects that protect neurons & support cognitive function important in damaged or stressed brains. https://share.google/OG3BgkkZrnSdk187t

 

While more research is needed to directly tie Tongkat Ali to BDNF increases, its systemic benefits provide a supportive backdrop for neuroplasticity: less inflammation, better metabolic balance, calmer stress response & improved neurochemical signaling.

The Daily Energy Story From Morning to Recovery

Imagine this as a daily narrative:

Morning:

🌞 You wake up with less heavy fatigue  cortisol is balanced, testosterone & mood are stable.

Midday:

💪 Your energy holds steady during physical therapy, walking, or cognitive tasks because stress is down & endurance feels higher.

Afternoon:

🧠 Your brain feels sharper & more resilient reduced “brain fog” & clearer thinking.

Evening:

😌 You sleep deeper & rest more fully, laying the foundation for tomorrow’s healing.

This cycle repeated day by day supports both physical & neurological recovery.

How Nu-Prep Tongkat Ali May Help Stroke Recovery

1️⃣ Daily Energy & Hormonal Balance

✔ Reduced stress hormones (cortisol)

✔ Improved testosterone balance

✔ Less fatigue, better mood

✔ Higher daily activity and therapy engagement

https://pubmed.ncbi.nlm.nih.gov/23705671/

 

2️⃣ Potential Brain Support Environment

✔ Balanced neurochemicals like dopamine

https://akarali.com/tongkat-ali-effects-dopamine/?utm_source=chatgpt.com

 

✔ Antioxidant and anti-inflammatory effects

https://www.researchgate.net/publication/333030748_Effects_of_Eurycoma_longifolia_Jack_on_chronic_cerebral_hypoperfusion-induced_oxidative_damage_and_memory_deficit_in_rats?utm_source=chatgpt.com

 

✔ Improved sleep and rest-activity rhythm in preclinical models

https://pubmed.ncbi.nlm.nih.gov/39055967/

 

3️⃣ Indirect Support for Neuroplasticity (BDNF-Friendly)

✔ Reduced stress encourages conditions where BDNF can thrive

https://pmc.ncbi.nlm.nih.gov/articles/PMC7204205/?utm_source=chatgpt.com

✔ Better mental & physical engagement accelerates rehabilitation efforts

✔ A holistic boost to the body’s internal recovery environment

 

 

Stroke recovery is both scientific & deeply personal. By offering a standardized, clinically studied extract like Nu-Prep Tongkat Ali, we provide not just energy, but a foundation for resilience hormonally, mentally & physically. This creates a fertile environment for the brain to heal, adapt & rebuild itself. For readers worldwide searching for holistic, evidence-informed daily support, this story connects ancient plant wisdom with modern recovery science in a way that resonates globally.

Stroke Recovery : Brain Derived Neurotrophic Factor. BDNF ( brian performance ).

 PART 1. ( faith in God, hard work, and science-supported products balanced and respectful ).

A Story of Integrity, Family, Faith, and Hope. 

Stroke Recovery.

My brother-in-law is 56 years old.

A man of uniform, discipline & high integrity.

He worked hard all his life, always standing firm in responsibility and values.

In 2023, he suffered a serious stroke, a second major attack, with a very high degree of impact.

After careful assessment, the doctors explained that recovery chances were extremely low.

Stroke Recovery

Medical options had reached their limit & as a family, we were advised to prepare for long-term responsibility.

It was not an easy decision but as an immediate family, we stood together. We believe that God is the best Planner & miracles are granted in ways beyond human prediction. To prevent further seizures or convulsions, all medication was eventually stopped under careful observation.

From there, a new chapter began.

A New Era: Love, Science, and Faith Combined

With full commitment, we introduced 100% traditional, standardized, water-soluble, freeze-dried extracts:

Nu-Prep

·        to support energy recovery and help control blood sugar levels

KESUM (Polygonum minus)

·        to support brain function, memory, and performance

KESUM is associated with Brain-Derived Neurotrophic Factor (BDNF), a key protein involved in:

·       Neuroprotection

·       Neurogenesis

·       Memory and cognitive recovery

Scientific findings indicate a ~2% increase in BDNF, a meaningful signal when dealing with neurodegenerative conditions.

 

We began this journey in April 2024, after Raya last year.

Due to swallowing limitations, all tablets & capsules are carefully crushed or ground before intake.

TODAY, 25^th December 2025, he can consume normal meals breakfast, lunch & dinner, something that was once impossible, when he could only manage mild intake a few times a day.

What Professionals Could Not Do, Family Did.

This level of care cannot be replaced by any professional service.

Only love, patience & unity within the family made this possible.

Progress was slow but meaningful.

Today, he has begun to:

·       Move his hands and legs

·       Practice daily communication

·       Respond more actively to surroundings

One moment touched us deeply:

He is now able to use a remote control, switching from Astro TV to YouTube searching & watching content related to stroke treatment & recovery.

This reflects a positive cognitive response a sign of awareness, intention & curiosity.

To us, this is nothing short of a miracle.

Science, Faith, and Gratitude

Previously, a neurologist once mentioned that his brain function was estimated at only 2%.

During a later review, the specialist asked:

“Is there any special treatment or supplement being taken?”

The answer was simple: Yes.

This journey is not about claiming miracles alone

It is about hard work, science-supported, clinically studied natural products, and faith in God’s grace.

We truly believe this recovery, however gradual is a great gift from God.

This is only the beginning.

More will be shared, soon.

Tongkat Ali: The Truth About Testosterone From Science, Not Drugs.

 Tongkat Ali: The Truth About Testosterone From Science, Not Drugs.

World Anti Doping Agency.

In a world flooded with exaggerated claims and counterfeit supplements, Jerry Brainum one of the most respected writers in sports science delivered a rare, honest breakdown of Tongkat Ali in his discussion “Tongkat Ali: Is it a true testosterone booster?”.

His conclusion was clear and important:

Yes, Tongkat Ali can genuinely support testosterone but only when it is real, clinically proven, and properly standardized. 

Tongkat ali: Is it a true testosterone booster?

1. Testosterone Boosting Without Drugs

Jerry Brainum explained that true Tongkat Ali does not act like anabolic drugs.

Instead, it works through natural physiological mechanisms, including:

·       Reducing excess cortisol (stress hormone)

·       Improving free testosterone availability

·       Supporting Leydig cell function

·       Enhancing overall hormonal balance

This means:

❌ No hormonal suppression

❌ No artificial stimulation

✅ Natural, adaptive testosterone support

This makes Tongkat Ali uniquely suitable for athletes, aging men, and physically active individuals who cannot afford drug like risks.

2. The Biggest Problem: Fake Tongkat Ali on the Internet

Jerry Brainum openly warned the international community:

·       Most Tongkat Ali sold online including on eBay and unverified platforms is fake, under-dosed, or not Tongkat Ali at all.

Common issues include:

·       Wrong plant species

·       No standardization

·       No human clinical trials

·       Contamination or spiking

This is why he stressed “doing your homework”  not trusting labels or marketing claims.

3. One Name Repeated in Scientific Literature: Biotropics Malaysia

In his review, Jerry Brainum highlighted that the only Tongkat Ali repeatedly supported by original human clinical studies comes from:

Key points:

·       Multiple peer-reviewed human clinical trials

·       Original research articles (not borrowed or extrapolated data)

·       Standardized extract with reproducible results

Used in research institutions, not influencer marketing

This places Biotropics’ Tongkat Ali in a completely different category from generic or commercial-grade extracts.

4. What Jerry Brainum Did Not Fully Emphasise - But Matters Greatly in Sports

Beyond clinical efficacy, Biotropics’ Tongkat Ali ( Nu-Prep ) achieved something no other testosterone-support supplement in the world has achieved:

·       🌍 World’s First Doping-Approved Testosterone-Supporting Supplement

(Herbal, Natural, Drug-Free)

✅ ONE & ONLY:

·       Standardised, Water-soluble, Freeze-dried, Clinically proven, DOPING-FREE

Approved through:

·       World Anti-Doping Agency (WADA) standards

·       Urine test verification, SEA Games 2017, 16 urine samples, Malaysian National Rugby Team

Result: 100% clean

Testing coordinated through: Institut Sukan Negara (ISN), Malaysia

 

5. Official Use in National Sports

As a result:

Only Tongkat Ali Nu-Prep by Biotropics Malaysia Berhad is permitted / allowed / trusted for national athletes under ISN supervision.

This is not marketing.

This is policy-level acceptance.

Why?

Athletes cannot risk contamination

Testosterone support must be drug-free

Supplements must pass real doping controls, not just lab certificates

 

6. Why This Is a Global Opportunity

For countries serious about:

·       Olympic sports, National teams, Professional leagues, Military & tactical performance, Youth athletic development.

This sets a new global benchmark:

·       Testosterone support does not need drugs it needs science, standardisation, and anti-doping integrity.

Jerry Brainum’s message was correct and responsible:

·       Tongkat Ali works, Most products are fake, Only clinically proven extracts should be trusted

What elevates this further is reality on the ground:

Malaysia is home to the world’s first and only doping-approved, clinically proven, herbal testosterone-support supplement Tongkat Ali Nu-Prep by Biotropics Malaysia Berhad.

This is not just a supplement. It is a new global reference standard for clean performance. 

Nu-Prep.

 https://vt.tiktok.com/ZSHK4ksgHgr1X-U9MA1/ .

https://shop.biotropicsmalaysia.com/

Buy with Confidence Direct from the Source.

For guaranteed authenticity, safety, and quality, we strongly recommend purchasing directly from Biotropics Malaysia Berhad or through its official, genuine website only.

Every product is:

·       100% Genuine & Clinically Supported

·       Manufactured under strict quality and safety standards

·       Backed by scientific research and decades of expertise in standardized herbal extracts

·       Free from counterfeit risks or unverified sources

By buying directly from Biotropics Malaysia Berhad, you are assured that what you consume is safe, traceable, and proven exactly as studied and validated.

Your health deserves nothing less than the original.

Choose certified. Choose safety. Choose Biotropics Malaysia Berhad.

"Tracing Your Focus on the Highway".

 A Gentle Reminder for Malaysian Drivers: Your Next Stop for Safer Highways

"Tracing Your Focus: The Coffee & Tongkat Ali PHYSTA Blend at PETRONAS Mesra".

Nu-Caffe with Tongkat Ali PHYSTA at PETRONAS Mesra: A Clinically-Verified Focus Formula for the Road. 

Nu-Caffe at PETRONAS Mesra Soon: The Science-Backed Choice for a Safer Journey Home. 

You’ve just pulled out of the PLUS Highway Tapah R&R (Southbound). At the counter of PETRONAS Mesra 801 (2023-2024), between the snacks and the drinks chillers, you find it: Nu-Caffe now formulated with Tongkat Ali PHYSTA. 

This isn't just coffee. It's a precision toolkit for sustained mental drive. For the driver navigating the stretch from Johor Bahru to Penang, focus isn't a luxury; it's a necessity. This blend pairs a clean caffeine kick with something deeply rooted in the Malaysian rainforest: the proven cognitive-support power of Eurycoma longifolia (Tongkat Ali).

Let’s verify the science. On your phone using your Maxis, Digi, or Celcom data search this exact phrase: "Eurycoma longifolia reduces fatigue and improves mood study 2013"

You will find a landmark double-blind, placebo-controlled study published in the Journal of the International Society of Sports Nutrition. The results are clear: supplementation with a standardised Tongkat Ali extract (the PHYSTA refers to its specific, clinically-tested phytochemical profile) led to significant reductions in tension, anger, and confusion, while vigour scores markedly improved. In driving terms: less mental fatigue, more sustained, calm alertness.

 

This is the PHYSTA advantage on your journey. While caffeine blocks adenosine receptors to delay the feeling of tiredness, Tongkat Ali works at a hormonal level to support the body’s response to physical and mental stress. Search further:

"Tongkat Ali cortisol stress clinical trial 2015"

You’ll find research indicating its role in promoting a healthier cortisol profile. High stress and mental fatigue often correlate with elevated cortisol. By helping to regulate this, Tongkat Ali PHYSTA supports the quality of your alertness promoting focus without the jagged edge.

 

Now, picture the ecosystem: A Grab driver completing a tenth ride in Kuala Lumpur's city centre needs steady concentration. A businessman driving back from a meeting in Shah Alam to Seremban must stay sharp. They stop at PETRONAS Mesra not just for fuel, but for a cognitive refuel. This creates a new, traceable customer pattern: the "Focus Stop."

Verify the Science: Search "standardised Tongkat Ali extract cognitive fatigue" or "Eurycoma longifolia RCT mood 2013".  

"True driving wellness is about sustainable focus. Nu-Caffe with Tongkat Ali PHYSTA at PETRONAS Mesra offers a combination backed by clinical research you can verify yourself. Share this with your network. Challenge them to trace the science and locate the product. Because in health and on the road, knowledge you can prove is the most powerful fuel of all."

Nu-Caffe

A Gentle Reminder for Malaysian Drivers: Your Next Stop for Safer Highways.

Nu-Caffe at PETRONAS Mesra Soon: The Science-Backed Choice for a Safer Journey Home.

 

Every journey on the PLUS Highway Malaysia begins with the same silent wish: to reach our destination safely. At PETRONAS Mesra, that wish is their first thought for you. It’s more than a convenience store; it’s a pit stop for your well-being. Soon, a new item will appear on its shelves one designed with that very promise in mind: Nu-Caffe, enriched with Tongkat Ali PHYSTA.

Imagine pulling into a PETRONAS Mesra at the Simpang Ampat R&R (Northbound), tired after hours on the road. Your focus is waning, and the long stretch to Juru still lies ahead. This moment, where fatigue meets the road is where a simple choice can support a safer outcome.

 

The upcoming arrival of Nu-Caffe is grounded in a mission: to contribute to safer Malaysian highways. How? By directly addressing a key factor in many accidents: driver fatigue and degraded mental focus.

 

This is not just hopeful thinking; it’s built on a clinical foundation. The core ingredient, Tongkat Ali PHYSTA (Eurycoma longifolia), is one of Malaysia’s own herbal treasures, now validated by modern science. To understand its role, you can verify this yourself:

Search on your phone right now:

"Eurycoma longifolia reduces fatigue and improves vigour study 2013"

 

Nu-Caffe

You will find the published research in the Journal of the International Society of Sports Nutrition. The results show that standardized Tongkat Ali extract significantly improved vigour scores and reduced negative mood states like tension and confusion. For a driver, this translates to sustained, calm alertness a mental state crucial for split-second decisions.

 

Furthermore, search:

"Tongkat Ali cortisol stress response study"

Research indicates its potential in promoting a healthier stress response. Lower perceived stress and mental fatigue can lead to more patient, focused driving. When Nu-Caffe becomes available at PETRONAS Mesra outlets along the North-South Expressway, it will offer a unique, two-fold support: clean caffeine for immediate alertness and Tongkat Ali PHYSTA for sustained, resilient focus.

 

This initiative represents a thoughtful layer to PETRONAS Mesra’s commitment. It’s the same commitment that ensures clean restrooms, well-lit forecourts, and friendly service all in service of your safety and comfort. Adding a scientifically-formulated cognitive aid to the mix is a natural next step.

 

Be Part of This Safer Journey:

Soon, when you stop at a PETRONAS Mesra near you, look for Nu-Caffe. It will be more than a drink; it will be a choice for a clearer mind on the road.

A Final, Soft Reminder:

PETRONAS Mesra has always been there for your fuel, your snacks, and your breaks. Soon, it will also be there for your focus. Because the true destination of every trip isn't just a place on a map it's the safety and well-being of everyone on the road.

Watch for it soon. Choose it for the journey. Let’s make our highways safer, together.

"The Science-Backed Hormone Breakthrough : How Tongkat Ali Supports Testosterone & Metabolic Health".

 Testosterone & Insulin Sensitivity / Glucose Metabolism (Human Evidence).  

Nu-Prep

#perfectprediction Normal

1.     Established associations in humans:

·       Low testosterone levels are strongly associated with insulin resistance and increased diabetes risk in men. Clinical studies show men with lower testosterone tend to have poorer insulin sensitivity.

PubMed https://pubmed.ncbi.nlm.nih.gov/40771640/

 

·       A clinical crossover study in hypogonadal men with type 2 diabetes showed that testosterone treatment improved insulin sensitivity, fasting glucose, and HbA1c (a long-term blood sugar marker).

PubMed  https://pubmed.ncbi.nlm.nih.gov/16728551/

 

·       Additional trials and meta-analyses report modest improvements in insulin resistance measures with testosterone therapy in metabolic syndrome contexts, though effects on glucose outcomes can vary by study and population.

Healthy Male.

https://healthymale.org.au/research-reviews/effects-testosterone-treatment-glucose-metabolism-and-symptoms-men-type-2-diabetes?utm_source=chatgpt.com

 

·       📌 Interpretation:

This body of clinical evidence confirms that hormonal improvements (higher testosterone) tend to correlate with better insulin action and some aspects of glucose metabolism in men with low testosterone or metabolic disorders (e.g., metabolic syndrome, type 2 diabetes or hypogonadism).

PubMed +1  https://pubmed.ncbi.nlm.nih.gov/16728551/  

 

Nu-Prep 

'sugar NORMAL'.

2.     Tongkat Ali (Eurycoma longifolia) & Testosterone (Clinical Evidence)

✅ Clinically confirmed:

A systematic review and meta-analysis of human randomized clinical trials shows that Eurycoma longifolia supplementation significantly increases total testosterone levels in men - both healthy individuals and those with low testosterone.

PubMed https://pubmed.ncbi.nlm.nih.gov/36013514/

 

·       Several independent clinical studies also show increased testosterone or total androgen levels after supplementation.

PMC   https://pmc.ncbi.nlm.nih.gov/articles/PMC9415500/?utm_source=chatgpt.com

 

·       📌 Interpretation:

The evidence supports that high-quality Tongkat Ali extract can raise serum testosterone in humans in controlled settings, making it a scientifically supported herbal testosterone booster.

PubMed https://pubmed.ncbi.nlm.nih.gov/36013514/

 

Nu-Prep 

Normal.

3.     Tongkat Ali & Glucose / Insulin Pathways (Mechanistic / Preclinical Evidence)

 

·       Preclinical laboratory and animal evidence:

Some research (animal studies) shows that Tongkat Ali extracts exhibited antihyperglycemic effects, including improved glucose tolerance and increased insulin secretion in diabetic animal models.

ResearchGate https://www.researchgate.net/publication/342995332_The_Powdered_Root_of_Eurycoma_longifolia_Jack_Improves_Beta-Cell_Number_and_Pancreatic_Islet_Performance_through_PDX1_Induction_and_Shows_Antihyperglycemic_Activity_in_dbdb_Mice?utm_source=chatgpt.com

 

·       In vitro studies have shown that Tongkat Ali extracts can enhance insulin secretion from pancreatic cells and increase glucose uptake into cells in lab models.

ResearchGate

https://www.researchgate.net/publication/321266071_Eurycoma_longifolia_Jack_water_extract_PhystaR_and_its_43_kilodalton_peptide_increase_insulin_secretion_from_pancreatic_cells_and_enhance_glucose_uptake_in_insulin-sensitive_cells_in_vitro  

 

·       Reviews of pharmacology note glucose-related effects in cell or animal studies, including enhanced glucose uptake and improved insulin signaling pathways.

MDPI https://www.mdpi.com/1420-3049/21/3/331?utm_source=chatgpt.com

 

·       📌 Important Clarification:

 

➡️ Human clinical evidence for Tongkat Ali directly improving blood sugar or insulin sensitivity in people is limited or absent so far.

➡️ The supportive evidence currently comes from animal models and lab mechanisms, not definitive human clinical trials.

➡️ Therefore any statements that Tongkat Ali directly lowers blood sugar in people should be clearly qualified as preclinical evidence, promising but not yet proven in humans.

 

PMC +1  https://pmc.ncbi.nlm.nih.gov/articles/PMC9415500/?utm_source=chatgpt.com

 

Nu-Prep

'sugar normal'. 

4.     What This Means for Messaging & Positioning

Supported by human clinical evidence:

·       ✅Tongkat Ali increases testosterone levels in men (RCTs + meta-analysis).

PubMed https://pubmed.ncbi.nlm.nih.gov/36013514/

·       ✅Higher testosterone in men is generally associated with better insulin sensitivity and improved aspects of glucose metabolism.

PubMed https://pubmed.ncbi.nlm.nih.gov/40771640/  

 

           Mechanistic / preclinical only (not yet clinical in humans):

·        Tongkat Ali’s effects on insulin secretion, glucose uptake, and direct blood sugar lowering mainly shown in animals and in vitro studies.

ResearchGate https://www.researchgate.net/publication/321266071_Eurycoma_longifolia_Jack_water_extract_PhystaR_and_its_43_kilodalton_peptide_increase_insulin_secretion_from_pancreatic_cells_and_enhance_glucose_uptake_in_insulin-sensitive_cells_in_vitro?utm_source=chatgpt.com  

 

·       📌 Appropriate scientific nuance for claims:

i.                    Tongkat Ali has strong clinical evidence for increasing testosterone. PubMed https://pubmed.ncbi.nlm.nih.gov/36013514/

 

ii.                   Higher testosterone is linked to improved metabolic pathways including insulin sensitivity. PubMed https://pubmed.ncbi.nlm.nih.gov/40771640/

iii.                 Preclinical studies suggest possible glucose regulatory pathways for Tongkat Ali, which make it a promising subject for future human studies. ResearchGate

https://www.researchgate.net/publication/321266071_Eurycoma_longifolia_Jack_water_extract_PhystaR_and_its_43_kilodalton_peptide_increase_insulin_secretion_from_pancreatic_cells_and_enhance_glucose_uptake_in_insulin-sensitive_cells_in_vitro?utm_source=chatgpt.com

 

Nu-Prep

HbA1C Normal

Summary Table  ✅

Topic	Human Clinical Evidence	Preclinic Support
Testosterone ↑ with Tongkat Ali	Yes - Meta-analysis & RCTs PubMed https://pubmed.ncbi.nlm.nih.gov/36013514/	NON -
Testosterone improving insulin sensitivity	Yes - in clinical hormone therapy contexts PubMed https://pubmed.ncbi.nlm.nih.gov/16728551/	NON -
Tongkat Ali improving glucose control in people	No direct human clinical trials yet	Yes - animal & in vitro studies ResearchGate https://www.researchgate.net/publication/342995332_ The_Powdered_Root_of_Eurycoma_ longifolia_Jack _Improves_Beta Cell_Number_and_Pancreatic_Islet_ Performance_through_PDX1_Induction_and_Shows_ Antihyperglycemic_Activity_in_ dbdb_Mice?utm_source=chatgpt.com