COVID-19. The Science Behind Male Vulnerability and the Emerging Role of PHYSTA® Tongkat Ali.

When Testosterone Fell, COVID-19 Became Deadlier.

A Scientific Story Connecting Hormones, Immunity & PHYSTA® Tongkat Ali.

During the peak of the COVID-19 pandemic, one observation consistently stood out across hospitals worldwide: men were dying at higher rates than women. For a long time, the reason was unclear.

 

That changed in July 2021, when Professor Andrea Salonia and his team from San Raffaele University Hospital, Milan, presented a landmark finding at the 36th Annual European Association of Urology Congress (EAU21).

Testosterone Test.

Study reveals that almost 90% of men have hypogonadism at the time of hospital admission for Covid-19.

What they discovered shocked even seasoned clinicians.

“I have never seen anything like this in my 25 years in the field.”

Prof. Andrea Salonia, EAU21, 2021

The Milan Discovery: Testosterone & COVID-19 Severity

In a cohort of 286 men hospitalized with COVID-19:

·       89.8% had low testosterone (hypogonadism) at admission

·       Only 14.9% of healthy controls showed low testosterone

The lower the testosterone level, the higher the risk of:

·       Severe disease

·       Intubation

·       Death

Ref : COVID-19 Is Associated With Low Testosterone in Men.

https://www.renalandurologynews.com/reports/male-hypogonadism-associated-with-sars-cov-2-severity-mortality-death/#:~:text=Low%20testosterone%20levels%20are%20highly,14.9%25)%20of%20health%20controls 

While the study did not definitively determine whether COVID-19 caused low testosterone or exploited it, the signal was unmistakable:

·       Low testosterone was strongly associated with poor COVID-19 outcomes and mortality in men. 

Men with low testosterone more likely to die from Covid-19.   

https://www.eurekalert.org/news-releases/707995#:~:text=Men%20with%20symptomatic%20Covid%2D19,cent%20of%20the%20healthy%20volunteers. 

This was not an isolated observation. Independent reports (including EurekAlert) reinforced the same conclusion:

·       men with low testosterone were significantly more likely to die from COVID-19.

·       Why Testosterone Matters in Viral Infections

Testosterone is not merely a “male hormone.” Scientifically, it plays critical roles in:

·       Immune regulation (T-cell balance, cytokine modulation)

·       Inflammation control (preventing cytokine overreaction)

·       Muscle, lung & metabolic resilience

·       Stress hormone (cortisol) suppression

When testosterone collapses:

Inflammation rises

Immune response becomes dysregulated

Recovery capacity weakens

COVID-19 did not just attack the lungs it exposed metabolic & hormonal vulnerabilities, particularly in aging or stressed men.

PHYSTA® Tongkat Ali: Where Hormonal Science Meets Antiviral Evidence

This is where PHYSTA®, the standardized water extract of Eurycoma longifolia (Tongkat Ali), becomes scientifically relevant not as speculation, but through published evidence.

1. Clinically Proven Testosterone Support

PHYSTA® is one of the most clinically studied Tongkat Ali extracts globally, with human trials demonstrating:

Restoration of testosterone levels in men with deficiency

Reduction of cortisol (stress hormone)

Improvement in energy, vitality & physiological resilience

These effects directly address the risk profile identified in severe COVID-19 patients.

2. Direct Antiviral Activity Against SARS-CoV-2 (In Vitro)

In May 2024, a peer-reviewed study published in the

Malaysian Journal of Pharmaceutical Sciences (Vol. 22, No. 1, pp. 77–86) reported:

“Antiviral activity of PHYSTA® standardized water extract of Eurycoma longifolia against SARS-CoV-2: An in vitro study”

PHYSTA® Tongkat Ali

Antiviral Activity of Physta®, Standardised Water Extract of Eurycoma longifolia against SARS-CoV-2: An in vitro Study

https://www.academia.edu/145229646/Antiviral_Activity_of_Physta_Standardised_Water_Extract_of_Eurycoma_longifolia_against_SARS_CoV_2_An_in_vitro_Study

Source: Universiti Sains Malaysia https://share.google/Ky3KJJ5TrNaso7M3u

Conducted by:

Biotropics Malaysia Berhad

Tropical Infectious Diseases Research & Education Centre (TIDREC)

University of Malaya

Key findings:

·       PHYSTA® inhibited SARS-CoV-2 replication in Vero cells

·       IC₅₀: 36.3 μg/mL (50% viral growth reduction)

·       No cytotoxicity at effective antiviral concentrations

·       Clear suppression of viral plaque formation within 72 hours

·       Favorable Selectivity Index (SI), indicating safety vs efficacy balance

Mechanistically, the antiviral activity was attributed to:

·       Eurycomanone

·       Saponins interfering with viral capsid protein synthesis

·       Immunomodulatory effects reducing excessive inflammation

3. Intellectual Property Protection

This discovery is further reinforced by a registered patent:

·       Patent No: PI2022005089

·       Title: Use of Eurycoma longifolia extract against Coronavirus

·       This reflects novelty, scientific merit & translational potential, not anecdotal use.

Connecting the Evidence Carefully & Scientifically

What the science allows us to say responsibly:

·       Severe COVID-19 is strongly associated with low testosterone in men

·       PHYSTA® is clinically proven to support testosterone

·       PHYSTA® has peer-reviewed in-vitro evidence showing inhibition of SARS-CoV-2

·       PHYSTA® demonstrates immune-modulating and anti-inflammatory properties

What science does not claim:

·       PHYSTA® is not positioned as a drug or a cure

·       In-vitro antiviral activity does not replace clinical COVID-19 treatment

 

Nu-Prep

Nu-Prep is powered exclusively by PHYSTA® a clinically studied, standardized Tongkat Ali extract.

The COVID-19 pandemic revealed a critical but under-recognized factor in men’s vulnerability: hormonal resilience, particularly testosterone status.

The convergence of:

·       European clinical observations (EAU21, Milan)

·       Hormonal biology

·       Peer-reviewed antiviral laboratory evidence

Clinically validated Tongkat Ali standardization (PHYSTA®)

places PHYSTA® in a unique scientific position not as speculation, but as a biologically plausible, evidence-supported natural intervention worthy of serious academic & clinical attention.

PHYSTA® is currently among the very few standardized herbal extracts with both:

·       Human clinical evidence for testosterone support &

·       Published in-vitro evidence against SARS-CoV-2

This does not close the chapter it opens a new one for future translational, clinical & preventive research at the intersection of men’s health, immunity & viral resilience.

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What Professionals Could Not Do, Family Did.

 How Clinically Studies Tongkat Ali May Support Stroke Recovery & Brain Repair. 

What Professionals Could Not Do, Family Did.

Polis DiRaja Malaysia

Royal Maiaysia Police.

cognitive 

recovery

What Professionals Could Not Do, Family Did.

A Quiet Comeback: When Life Returns, Step by Step

At 57 years old, after a long and difficult journey with chronic stroke, something meaningful has begun to happen not loudly, not dramatically, but clearly.

Once a police officer serving at IPK Kuala Lumpur Polis DiRaja Malaysia 'Royal Malaysia Police', a man shaped by discipline, duty & resilience, he had reached a point where even specialists said, “We have done everything possible.”

Hospital treatment ended. Medications were stopped. Responsibility shifted fully into the hands of his wife & children.

The First Signs of Return.

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At the beginning, swallowing & chewing were limited. Medicines had to be managed carefully. Words were trapped in the mind. Hands & legs were slow, heavy, unresponsive.

Today, the changes are undeniable:

·       He is now able to take daily medicines normally, like any other person

·       He can chew medication, no longer dependent on modified forms

He follows a regular daily routine:

·       Breakfast, Lunch, Dinner

These may sound simple but in stroke recovery, this is not simple.

This is foundation regained. When the Voice Comes Back

Perhaps the most touching change is this:

·       He has begun to talk.

·       Not perfectly.

·       Not fluently.

But intentionally.

With daily training, repetition, patience & encouragement, words are returning. This is not accidental. It reflects neural re-engagement the brain finding alternative pathways when old ones were damaged.

In my experience across many chronic stroke patients, speech returning after a long plateau is one of the strongest signs of ongoing neuroplastic potential.

 

It means:

·       The brain is still listening

·       Still adapting

·       Still alive to training

Alongside speech, his body is responding:

·       Hands move more freely

·       Legs respond better

·       Coordination is improving

This is not a sudden miracle in the movie sense.

Across cases I’ve seen, this level of improvement usually appears when three things align:

·       Emotional safety (family presence)

·       Daily routine (structure)

Consistent stimulation (movement, speech, intention)

Your family created all three.

Is This a Miracle?

Yes, but not the kind that breaks science. 

remote - Astro 

BDNF

It is the kind of miracle that happens when:

·       The body is no longer over-medicated

·       The mind is no longer treated as “finished”

·       The patient is seen as a person, not a prognosis

·       Many chronic stroke patients are stable, but stagnant.

Few are gently pushed forward every single day.

That is the difference here. 

What This Stage Truly Means (From Experience)

You are no longer in the “hospital phase”. You are in the reclaiming phase.

For a man who once served the public with discipline & strength, this journey is not about going back to who he was. It is about becoming functional, dignified, connected & present, again. And what is happening now is real.

Not hope, Not imagination, Progress.

 

When Medicine Reached Its Limit, Care Did Not

After months of hospital care, procedures & specialist-led treatment, the conclusion was clear and heavy:

“We have done everything medically possible.”

·       For the family, especially the wife, this was not a rejection it was an ending.

·       An ending of hospital dependence.

·       An ending of uncertainty inside clinical walls.

 

When professional medicine could no longer offer direction, the wife made a conscious, courageous decision:

·       To stop all specialist-prescribed medication totally & take full responsibility for the next chapter.

·       This was not done lightly.

·       It was done with presence, observation & accountability.

A Different Path Begins

Instead of chasing more interventions, the focus shifted to recovery support:

·       Nu-Prep, taken daily to support energy, strength & day-long recovery rhythm

·       KESUM, introduced to support cognitive engagement, alertness & mental responsiveness

These were not seen as “cures”.

They were chosen as supportive tools to help the body function, to help the mind stay engaged & to give the patient a reason to participate in each day.

What Followed Was Not Immediate. But It Was Real

Slowly, signs appeared:

·       He began to eat normally breakfast, lunch & dinner

·       He could chew medicine, no longer needing special assistance

·       Energy became more consistent throughout the day

·       His attention improved

·       His voice returned, requiring daily training, patience & repetition

·       His hands and legs moved more, with clearer intent & control

In long-term recovery experience across many patients, this pattern is familiar:

·       When energy stabilizes and cognition re-engages, function often follows.

Not overnight.

But progressively.

Hope. With Grounded Understanding

The family now hopes that recovery will continue faster, stronger & more consistent.

That hope is human. And it is valid, when paired with realism.

From experience across recovery cases:

·       Some improvements accelerate

·       Some plateau

·       Some return unexpectedly later

 

What matters most is that:

The patient is awake to life, Engaged, Nourished, Supported daily

Surrounded by intention, not resignation

 

This Is Not Against Medicine

This story is not about rejecting doctors.

It is about recognizing a moment when:

Clinical intervention ended

Human care began to lead

And sometimes, especially in chronic neurological conditions, that transition is where meaningful change happens.

A Quiet Truth

Not every recovery is loud.

Not every improvement is dramatic.

But when a man who was once silent begins to speak again,

when hands respond,

when meals are shared regularly,

when energy lasts through the day

That is not denial.

That is life returning.

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Recovery - Energy.

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"Beyond Conventional Medicine: PHYSTA® Tongkat Ali and the Future of Evidence-Based Preventive Health".

 “Blood Sugar - Regulated Nu-Prep Tongkat Ali. Better Treatment” plus clinical evidence & data on PHYSTA® Tongkat Ali water-soluble freeze-dried extract.  

 “Blood Sugar - Regulated Nu-Prep Tongkat Ali. Better Treatment”

Nu-Prep PHYSTA® Tongkat Ali

Note: https://www.youtube.com/watch?v=fZZdli0d1ZA video content focused on claims around blood sugar, testosterone & “better treatment than medicine”.

 

🌿 The Science Meets Modern Medicine: Tongkat Ali (Eurycoma longifolia)

Tongkat Ali, scientifically Eurycoma longifolia is a traditional Southeast Asian herbal root used for centuries for vitality, mood, libido & overall well-being. Modern medicine approaches such supplements through rigorous clinical trials, biomarkers & safety profiling rather than anecdote or folklore.

Wikipedia https://en.wikipedia.org/wiki/Eurycoma_longifolia?utm_source=chatgpt.com

 

But not all Tongkat Ali is the same & here’s where PHYSTA® stands apart.

🔬 What Makes PHYSTA® Special in Modern Clinical Terms

Standardized Water Soluble Freeze-Dried Extract

PHYSTA® is produced using a patented hot-water extraction & freeze-drying process designed to preserve the full spectrum of water-soluble bioactives especially eurycomanone, peptides, glycosaponins  antioxidants that are otherwise degraded by heat or alcohol extraction methods used in many supplements.

Nu Prep +1 https://nuprep.com.my/en/physta-r?utm_source=chatgpt.com

 

Quality & Regulatory Rigour

It is developed under strict Ministry of Health Malaysia, ISO, GMP & Halal certifications, with documented toxicology & quality studies validating consistency & safety.

Nu Prep https://nuprep.com.my/en/physta-r?utm_source=chatgpt.com

 

Clinical Research ‘Not Just Claims’

Unlike generic herb powders, PHYSTA® has multiple published human clinical studies that validate measurable biological effects a key requirement in evidence-based medicine.

PubMed +2 https://pubmed.ncbi.nlm.nih.gov/41283187/

 

 

🧠 What Western Medicine Actually Cares About

Physicians & scientists evaluate supplements based on:

Randomized Controlled Trials (RCTs) the gold standard in clinical research.

Validated Outcome Measures - testosterone levels, validated symptom scales, immune profiles, quality-of-life indices.

Safety & Tolerability - lab values, organ function tests, adverse event monitoring.

PHYSTA® has satisfied all three in multiple independent studies.

📊 Key Clinically Proven Effects of PHYSTA®

✅ 1. Testosterone & Quality of Life in Aging Men

A 12-week RCT showed that PHYSTA® significantly increased serum total testosterone & reduced ageing-male symptoms & fatigue compared to placebo. Higher doses showed early effects starting as soon as 2–4 weeks.

PubMed https://pubmed.ncbi.nlm.nih.gov/34262417/

 

✔ These are objective hormone & symptom improvements, not subjective marketing hype.

✅ 2. Sexual Function and Performance

In a double-blind, placebo-controlled trial, PHYSTA® combined with Polygonum minus significantly improved erectile function scores, erection hardness & male symptom scores compared to placebo.

PubMed https://pubmed.ncbi.nlm.nih.gov/24550993/

 

✔ These endpoints are validated by medicine as real functional outcomes not vague “vitality” claims.

✅ 3. Quality of Life in Women (Menopause)

A first-of-its-kind 12-week clinical trial in menopausal women found that PHYSTA® reduced total menopausal symptom scores by ~34%, with statistically significant improvements in physical & sexual domains.

PubMed +1 https://pubmed.ncbi.nlm.nih.gov/41283187/

 

✔ Shows gender-inclusive effects, widening clinical relevance beyond men.

 

✅ 4. Immune Modulation

A randomized study in adults showed PHYSTA® improved immunological vigor including increases in T-cell counts & immune grading after 4 weeks.

PubMed https://pubmed.ncbi.nlm.nih.gov/26816234/

 

✔ Immune enhancement is a measurable, clinically relevant endpoint especially in aging populations.

🧪 Modern Medicine’s Traditional Skepticism & How PHYSTA® Answers It

❓ Skepticism: “Supplements are unproven & unregulated.”

👉 Answer: PHYSTA® is one of the few extracts with multiple peer-reviewed human trials, standardized bioactive markers & regulated production standards matching what doctors expect from evidence-based therapeutics.

Nu Prep https://nuprep.com.my/en/physta-r?utm_source=chatgpt.com

 

“Herbal extracts can be adulterated or inconsistent.”

👉 Answer: Over 30 clinical & toxicology studies, authenticated raw materials & patented extraction eliminate guesswork, rejecting low-quality market products that sometimes contain contaminants or no active compounds at all. アスク薬品株式会社  

 

 

🧬 How PHYSTA® Works  ‘A Scientific Story’

Instead of focusing on symptoms alone, modern medicine asks:

What pathways are affected?

👉 PHYSTA® has shown:

·       Hormonal modulation (improved testosterone, balanced stress hormones)

·       Immune enhancement (increased immune grades and T-cells)

·       Improved cellular energy & physical function

·       Better mood & quality of life metrics

 

These are measurable, reproducible biological effects not simply placebo.

PubMed +1 https://pubmed.ncbi.nlm.nih.gov/34262417/

 

 

📖 A New Paradigm in Health

Imagine the standard medical care model:

·       Diagnostic → Prescription drug → Single effect

·       Often treats one symptom or one pathway.

·       Higher side-effect load.

Now contrast this with a clinically proven botanical like PHYSTA®:

·       🌿 Holistic modulation - not just one receptor or hormone but multiple pathways.

·       📈 Objective improvements - hormone balance, mood, endurance, immune resilience.

·       ⚖️ Safety profile - no significant labs changes, favorable tolerability.

PubMed https://pubmed.ncbi.nlm.nih.gov/34262417/

 

 

This is not a magic herb - it is an evidence-backed multi-endpoint botanical intervention. Western medicine rarely gives such credit unless it can see clear data & PHYSTA® delivers it.

🌟 PHYSTA® Tongkat Ali isn’t just another supplement - it is clinically validated, standardized, & measured against real medical endpoints. Unlike generic herbal extracts:

·       ✅ Evidence across age ranges (men & women)

·       ✅ Increases testosterone naturally

·       ✅ Enhances libido, strength, mood

·       ✅ Supports immunity

·       ✅ Demonstrates safety in controlled human trials

In the language of Western medicine, PHYSTA® is an adaptogenic botanical with measurable endocrine, immune & quality-of-life benefits, supported by clinical research a bridge between natural tradition & modern evidence.

PubMed +2 https://pubmed.ncbi.nlm.nih.gov/41283187/ 

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PHYSTA® Tongkat Ali

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