Neuroprotection & Viral Outbreaks: Relevance in the Context of Nipah Virus

 Neuroprotection & Viral Outbreaks: Relevance in the Context of Nipah Virus.

NIPAH VIRUS.

A research study on neuroprotective mechanisms, while making NO direct claim to treat or prevent viral infection, demonstrates processes that are highly relevant to outcomes during neurotropic viral outbreaks. This is a critical distinction between direct antiviral action & host-directed therapy aimed at preserving brain integrity.

 

Why This is an Astute Connection: The Case of Nipah Virus

 

1. Nipah Virus as a Model Neurotropic Pathogen

 

·       Primary Pathology: Causes severe encephalitis (brain inflammation).

·       Key Damage Mechanisms:

·       Direct neuronal infection and cell death.

·       Immune-mediated "bystander damage": Excessive inflammation (cytokine storm), microglial activation & vasculitis (inflammation of blood vessels) contribute significantly to brain injury.

·       Blood-Brain Barrier (BBB) disruption, allowing further viral & inflammatory entry.

 

2. Parallel Neuroprotective Targets (from a hypothetical study)

A study showing compounds or pathways that achieve the following would be directly pertinent:

Neuroprotective Mechanism Relevance to Nipah Virus Encephalitis

Reducing excitotoxicity (e.g., via glutamate modulation) Could protect neurons from inflammation-induced excitotoxic death.

Inhibiting microglial overactivation / neuroinflammation Could dampen harmful bystander injury without affecting antiviral immunity.

Strengthening Blood-Brain Barrier integrity Could limit viral CNS entry & reduce vasogenic edema.

Promoting neuronal resilience (e.g., via autophagy, ER stress reduction) Could help infected or neighboring neurons survive longer, buying time for immune clearance.

 

Anti-apoptotic pathways Could prevent premature neuronal suicide triggered by infection.

 

The Strategic Implication: Host-Directed Adjunctive Therapy

Concept: In a neurotropic viral outbreak, the treatment strategy has two arms:

 

1. Direct Antiviral Arm: Attack the virus. (e.g., monoclonal antibodies, antivirals - often limited for novel viruses).

2. Host-Directed Therapeutic (HDT) Arm: Protect the brain. This is where neuroprotection research becomes vital.

 

During an outbreak, an existing, well-characterized neuroprotective agent could be investigated for repurposing as an adjunctive therapy. Its goal wouldn't be to lower viral load, but to reduce mortality and neurological sequelae in patients who develop encephalitis.

 

Outbreak Preparedness & Research Priorities

This connection argues for:

1. Pre-Clinical Research: Screening known neuroprotectants in vitro & in animal models of viral encephalitis (including Nipah).

2. Mechanistic Understanding: Clearly defining how a neuroprotective agent works (e.g., on inflammation, BBB) to predict its utility in an infectious context.

3. Stockpiling & Protocols: For high-threat neurotropic viruses, having a vetted, safe neuroprotective agent ready for adjunctive clinical trials during an outbreak could save crucial time.

4. Dual-Use Research: Framing fundamental neuroprotection research with an awareness of its potential application in infectious disease crises.

 

Important Caveats & Considerations

 

·       Timing is Critical: Neuroprotection must be initiated early in the disease course, before irreversible neuronal loss occurs.

·       The Immune Balance: Any intervention must not inadvertently suppress the adaptive immune response needed to clear the virus.

·       Pathogen-Specific Factors: Some viruses induce unique pathology (e.g., Nipah's syncytia formation); the ideal neuroprotectant should address the predominant damage pathways.

 

Research into neuroprotection is not just for stroke or neurodegeneration. It is a critical component of preparedness for outbreaks of neurotropic viruses like Nipah, Hendra, or even severe cases of West Nile or Japanese encephalitis. By focusing on preserving the brain's infrastructure, we create a potential second line of defense that works alongside antivirals & vaccines to improve survival & long-term neurological outcomes.

Unusually Specific & Multi-Faceted Mechanism for a Botanical:

Most cognitive supplements (e.g., Bacopa, Ginkgo, Lion's Mane) provide generalized support & may increase BDNF, but their clinical data rarely delineates effects on neurogenesis, neuroprotection & specific neurodegeneration pathways so clearly in human trials.

 

·       Neuroprotective: The significant reduction in inflammatory markers (iNOS -51%, MDA -7.4%) & high antioxidant capacity (ORAC value, CAP-e assay) provide a clear neuroprotective mechanism by combating oxidative stress & inflammation, two key drivers of neuronal damage.  

 

·       Neurodegeneration & Neurogenesis: The increase in BDNF (+2% vs. placebo's -19% decrease) is a direct biomarker linked to neurogenesis (the growth of new neurons) & synaptic plasticity. The 19% increase in DLPFC activation (a critical brain region for executive function) further supports enhanced neural efficiency and health.

 

·       Multi-Systemic Benefits: The improvement in lipid profile (19% reduction in triglycerides) is a significant finding. It suggests the extract's benefits may extend to supporting cerebrovascular health, which is intrinsically linked to cognitive function & protection against neurodegeneration.

 

The three human clinical trials are its greatest strength. The studies are well-structured (randomized, double-blind, placebo-controlled), involve different age groups (middle-aged and elderly) & show statistically significant results in:

 

·       Objective Cognitive Metrics: Processing speed, visual memory, executive function & complex task completion.

 

·       Subjective Mood Metrics: Notable reductions in tension, anger, confusion & anxiety.

 

·       Biological Biomarkers: BDNF, inflammatory markers & brain activation via imaging (DLPFC).

 

 

 

 

BIOKESUM ‘Standardization & Quality’,

Standardization to Quercetin-3-Glucuronide (Q3G) & total polyphenols ensures batch-to-batch consistency & efficacy, moving it from a mere "herb" to a reliable phytopharmaceutical-grade ingredient. The quality assurance certifications (FDA GMP, EUIPO) add significant credibility.

 

Viral Outbreaks Occur  & Neuroprotection (Nipah Virus Context):

Your point is astute. While this study makes NO claim to treat or prevent viral infection, the mechanisms it demonstrates are highly relevant to the context of neurotropic viruses like Nipah.

·       Nipah virus causes severe encephalitis, leading to neuronal inflammation, oxidative damage & potentially long-term cognitive deficits in survivors.

·       A substance with proven anti-inflammatory (reduces iNOS, COX), antioxidant (high ORAC, protects live cells per CAP-e), and BDNF-boosting properties could, in theory, contribute to a more resilient neural environment. The concept is "pre-hardening" or supporting brain health to potentially mitigate the severity of insult from an infection or other inflammatory triggers. This is a frontier area of research known as "neuroresilience."

 

BioKesum® represents a significant advancement in the field of cognitive nutraceuticals. It is not merely another general brain health supplement but appears to be a multi-target, phytochemically-defined intervention with compelling human data.

 

Its unique value proposition lies in the convergence of:

 

·       Clear Mechanisms: Antioxidant, anti-inflammatory, anticholinesterase & BDNF enhancement.

·       Validated Human Outcomes: Improved cognitive domains, better mood & favorable biomarker changes (BDNF, triglycerides, brain activation).

·       High-Quality Standardization: Ensuring therapeutic reliability.

 

Compared to common supplements like Bacopa, Ginkgo, or Fish Oil, BioKesum® distinguishes itself with a more comprehensive & specifically documented profile targeting the interconnected pathways of neurodegeneration, neuroprotection & neurogenesis, all backed by longitudinal human clinical trials.

 

 

This extract has crossed the threshold from traditional use into evidence-based nutritional neuroscience. Its potential application extends beyond general cognitive wellness into strategic support for brain health in the face of inflammatory, age-related, or other insult-driven challenges. The data provided makes a strong case for its inclusion in advanced formulations for cognitive longevity & resilience.

 

Disclaimer: This analysis is based on the materials you provided. For any health-related decisions, consultation with a healthcare professional is essential. The comments regarding viral outbreaks are theoretical & based on mechanism, not on direct evidence for treating or preventing Nipah virus infection.

KESUM https://shop.biotropicsmalaysia.com/biotropics-en

When Viral Outbreaks Occur: Strengthening the Body Through Rational Science.

When Viral Outbreaks Occur: Strengthening the Body Through Rational Science. ( Nipah Virus )

NIPAH VIRUS

NIPAH VIRUS

PHYSTA® Tongkat Ali: What the Evidence Really Shows

When viral outbreaks occur, the key question is not “what cures the virus?” - because that belongs to medicine & public health - but rather:

How can the body be better prepared to cope with stress, immune strain, and recovery?

This is where rational science, not hype, comes in.

What PHYSTA® Really Shows (in simple terms)

PHYSTA® Tongkat Ali is not just a traditional herb. It is one of the most clinically studied herbal extracts in Southeast Asia.

From the evidence available:

Preclinical studies show PHYSTA® can interfere with viral replication in laboratory models (e.g. Dengue virus, SARS-CoV-2).

Human clinical studies consistently show:

Reduced stress hormones (cortisol)

Improved energy & fatigue resistance

Better hormonal & immune balance

Improved physical & mental resilience

👉 This means PHYSTA does not treat viral disease, but it helps the body remain functionally stronger under stress.

In outbreak situations, stress overload & immune dysregulation often worsen outcomes. PHYSTA’s value lies in supporting the host, not attacking the virus directly.

Why KESUM Complements This (Neuro-Recovery Focus)

Certain viruses, especially severe ones, can affect:

The nervous system

Brain inflammation

Cognitive & neurological recovery

KESUM (Polygonum minus) is associated with:

Antioxidant protection

Neuro-supportive pathways

BDNF-related mechanisms (important for brain repair & resilience)

KESUM does not prevent infection, but it supports brain health & recovery capacity, which is often overlooked during & after viral stress.

The Dual Scientific Concept (Clearly Explained)

This is not a recommendation & not a treatment claim.

It is a rational scientific framework:

PHYSTA®

→ systemic resilience

→ stress regulation

→ immune balance

→ potential antiviral activity shown only in preclinical models

KESUM

→ neuroprotection

→ cognitive & brain recovery support

→ antioxidant defense

Together, they address two vulnerable areas during viral stress:

Whole-body resilience

Neurological recovery capacity

This is supportive science, not exaggeration.

Important Boundary (Very Clear)

❌ These supplements do not prevent viral infection

❌ They do not replace vaccines, antivirals, or medical care

❌ They do not treat outbreaks

 

✅ They may help strengthen immune balance & physiological resilience, especially during periods of high stress & recovery - when used responsibly.

 

In urgent or high-stress scenarios, PHYSTA® & KESUM can be viewed as supportive nutritional tools, grounded in rational science, aimed at strengthening the body’s resilience & recovery capacity - not as medical solutions.

 

PHYSTA® & KESUM: Supporting the Body During Viral Stress

During viral outbreaks, the goal is not to replace medical treatment, but to help the body stay strong, balanced & resilient.

PHYSTA® Tongkat Ali is one of the most researched herbal extracts from Malaysia. Scientific studies show that it helps:

Reduce stress & fatigue

Support hormonal & immune balance

Improve overall physical & mental resilience

Laboratory research has also shown that PHYSTA® can inhibit certain viruses in controlled settings. While this does not mean it treats viral infections, it suggests the herb may support the body’s natural defenses.

KESUM (Polygonum minus) focuses on a different but important area - the brain. It is known for:

Antioxidant protection

Supporting brain health & recovery

Helping the body cope with neurological stress

Why This Combination Makes Sense

PHYSTA® helps the body manage stress & immune strain

KESUM supports brain protection & recovery

Together, they support the body during periods of high stress, including recovery phases after illness.

This is supportive nutrition, based on rational science - not a cure, not a treatment & not a substitute for medical care.

 

 

PHYSTA® (Eurycoma longifolia) has demonstrated stress-modulating, fatigue-reducing & immune-balancing effects in multiple human clinical studies. Preclinical research has also reported antiviral activity against selected RNA viruses in in-vitro and animal models. These findings indicate potential supportive roles in physiological resilience, but do not constitute evidence of antiviral treatment or disease prevention in humans.

KESUM (Polygonum minus) has been associated with antioxidant & neuro-supportive properties, including pathways related to cognitive resilience & recovery. Its role is supportive in nature, particularly in maintaining neurological health under physiological stress.

The combined use of PHYSTA® and KESUM represents a rational, host-supportive nutritional approach aimed at enhancing systemic resilience & recovery capacity during periods of elevated physiological stress. These supplements are not intended to diagnose, treat, cure, or prevent any disease & should be used responsibly alongside appropriate medical guidance.

PHYSTA Tongkat Ali Nu-Prep  https://share.google/aPFuTOEcwKsoFBAJW

KESUM https://shop.biotropicsmalaysia.com/biotropics-en

The World's Best Tongkat Ali: Physta® by Biotropics Malaysia

One Source. One Truth. One Global Standard.

The Unmatchable Origin Story.

From the untouched rainforests of Malaysia comes a gift of nature - Physta®, the world’s most clinically researched Tongkat Ali extract.

Tongkat Ali

What makes it truly one-of-a-kind?

 

·       ✅ Sourced exclusively from Eurycoma longifolia var. Jack - a unique Malaysian variant, sustainably harvested & ecologically preserved.

·       ✅ Protected by international patents - ensuring purity, consistency & authenticity.

·       ✅ The only herbal facility in Malaysia inspected & approved by the USFDA (EIR) - a testament to world-class manufacturing integrity.

 

Tongkat Ali

Scientifically Unparalleled: The Evidence Speaks

With 32 clinical trials conducted worldwide, Physta® isn’t just an extract - it’s a scientifically validated phenomenon.

Here’s what the research confirms:

 

✅ Men’s Health & Vitality – 9 Clinical Studies

 

· Naturally supports testosterone levels, fertility & sexual wellness.

 

✅ Sports & Performance - 5 Clinical Studies

 

· Enhances energy, endurance & muscle strength.

 

✅ Healthy Aging - 2 Clinical Studies

 

· Boosts immunity & helps manage stress.

 

✅ Women’s Health – 1 Clinical Study

 

· Emerging research shows promise for hormonal balance & vitality.

 

✅ Broad-Spectrum Health Support – Multiple Studies

 

· Investigated for antiviral potential (Dengue, COVID), glucose management & kidney health.

 

Tongkat Ali

🌍 Global Research Credibility

 

Physta® has been validated by an international network of research institutions, including:

 

· USA: Medicus Research, HG Labs, USDA

· EU: BSI Germany, WIL Research Netherlands

· ASIA: Intertek China, Taipei Medical University, Jai Research Foundation

· MALAYSIA: USM, Hospital Universiti Sains Malaysia

· SOUTH AFRICA: University of Western Cape

 

This collaborative, worldwide scientific effort ensures transparency, reproducibility & trust. 

Tongkat Ali

📊 By the Numbers: Unbeatable Clinical Pedigree

 

· Total Clinical Studies Completed: 32

· Physta®-Specific Clinical Trials: 14

· Published Research on Physta® & Related Extracts: 26

· Biotropics Physta® Published Studies: 12

 

No other Tongkat Ali extract comes close to this depth of clinical validation.

🏆 Why Physta® Stands Alone

 

1. Born from Prestige - Jointly developed with MIT (Massachusetts Institute of Technology) & the Government of Malaysia.

2. Globally Recognized - Marketed and trusted in the USA, Europe, Asia & beyond.

3. Consumer Confidence - Backed by science, endorsed by health professionals & loved by users worldwide.

4. Malaysian Pride - A national treasure, sustainably sourced & globally celebrated.

 

✨ The Final Word

 

When you choose Physta®, you’re not just choosing a supplement -

you’re choosing the original, the patented, the clinically proven Tongkat Ali extract.

 

One country. One plant. One global standard.

Biotropics Malaysia Berhad

Bringing Nature’s Intelligence to Life. 

Nu-Prep Tongkat Ali

https://nuprep.com.my/

ED, Heart Health, and the Prostate: Where Does PHYSTA® Tongkat Ali Fit?

PHYSTA Tongkat Ali: Can This Clinically-Researched Herb Address the Heart-ED-Prostate Triad?

Let's examine the potential role of PHYSTA Tongkat Ali within the framework we've established where heart health is the foundation, ED is an early warning sign & prostate health is interconnected through shared pathways.

PHYSTA Tongkat Ali.

Understanding PHYSTA Tongkat Ali.

NU-PREP

PHYSTA TONGKAT ALI

PHYSTA® is a standardized extract of Eurycoma longifolia (Tongkat Ali) produced by Biotropics Malaysia Berhad. The standardization is crucial - it ensures consistent bioactive compound content (primarily eurypeptides, eurycomanone & glycosaponins), unlike unregulated raw root powders. The "more than 17 clinically proven" claim refers to the number of human clinical trials conducted with this specific extract.

 

The Evidence Map: What the 26+ Clinical Studies Show

 

The research breaks down into key areas relevant to our triad:

 

1. For Hormonal & Sexual Health (Direct ED Support)

 

· Testosterone Modulation: Multiple studies show PHYSTA can increase free & total testosterone in men with sub-optimal levels (hypogonadism), particularly age-related decline. A 2013 study in Evidence-Based Complementary & Alternative Medicine showed significant testosterone increases after 12 weeks.

· Improved Erectile Function: Research in the International Journal of Impotence Research demonstrated improvements in IIEF (International Index of Erectile Function) scores, particularly for erectile hardness & sexual satisfaction.

· Mechanism: It appears to work by reducing Sex Hormone-Binding Globulin (SHBG), freeing up more bioactive testosterone & potentially supporting luteinizing hormone production.

 

2. For Stress & Metabolic Health (Indirect Heart & ED Support)

· Cortisol Reduction: A key study in the Journal of the International Society of Sports Nutrition found PHYSTA significantly reduced cortisol levels (the stress hormone). This is critical because chronic high cortisol:

  1. Damages endothelium (hurting heart health and erections)

  2. Promotes abdominal fat (worsening metabolic syndrome)

  3. Lowers testosterone

· Improved Body Composition: Several trials show reduced body fat percentage & increased muscle mass - both beneficial for metabolic & cardiovascular health.

 

3. For Prostate Health - The More Nuanced Picture 

NU-PREP

PHYSTA TONGKAT ALI

 

· Not a Direct Treatment for BPH or Cancer: PHYSTA is not proven to shrink an enlarged prostate or treat prostate cancer.

· Supportive Role via Hormonal Balance: By optimizing testosterone levels (rather than drastically increasing them), it may support healthy prostate function. The "estrogen hypothesis" suggests that as men age, testosterone converts to estrogen, which may contribute to BPH. Balanced testosterone might mitigate this.

· Anti-inflammatory Properties: Some in-vitro studies suggest anti-inflammatory effects, which could theoretically benefit prostatitis (inflammation of the prostate), but strong human clinical data here is lacking.

 

Integrating PHYSTA into the Heart-ED-Prostate Framework

Let's revisit our flowchart and see where PHYSTA might intervene:

 

Poor Lifestyle & Genetics + Chronic Stress

       ↓

High Cortisol + Metabolic Syndrome

       ↓                       ↓

 Low Testosterone     Endothelial Dysfunction

       ↓                       ↓

 **Low Libido & ED**   Atherosclerosis Begins

       ↑                       ↑

       └─── PHYSTA MAY HELP HERE ──┘

      (Reduces Cortisol, ↑ Free Testosterone)

 

Professional Analysis of the Potential Benefits:

1. For ED as an Early Warning Sign: If ED is partly driven by low testosterone & high stress (common in modern men), then PHYSTA could address these contributing factors. This makes it a potential adjunct to lifestyle changes, not a replacement. It does not directly treat endothelial dysfunction - that requires diet, exercise & medical management of blood pressure/cholesterol.

2. For Heart Health (Indirectly): Its benefits are primarily upstream:

   · Cortisol Management: Chronic stress is a major, under-addressed cardiac risk factor. Lowering cortisol is profoundly cardioprotective.

   · Improving Body Composition: Reducing fat mass improves metabolic parameters.

   · However: PHYSTA is NOT a substitute for statins, blood pressure medications, or aerobic exercise. It supports the environment in which the heart thrives.

3. For Prostate Health (Cautiously): For a generally healthy prostate, hormonal balance is favorable. Crucial Caveat: Men with existing prostate cancer or significant, symptomatic BPH should consult a urologist before use. While no evidence suggests it causes harm, the androgen-sensitive nature of the prostate warrants medical supervision.

 

The Verdict: A Supporting Actor, Not the Lead

 

PHYSTA Tongkat Ali is one of the best-researched herbal supplements for male hormonal & stress support. Its 26+ clinical trials give it a legitimacy that most botanicals lack.

 

Who Might Benefit Most?

 

· Men with stress-driven, low-T related ED alongside lifestyle issues.

· Those seeking a natural adjunct to improve vitality, body composition & stress resilience as part of a broader heart-health prevention plan.

· Healthy men looking for evidence-based support during age-related hormonal shifts.

 

Critical Limitations & Warnings

 

· It is not a magic bullet for heart disease or prostate disease.

· It will not reverse ED caused by severe vascular damage or nerve injury (e.g., post-prostate surgery).

· Quality is paramount. Only use properly standardized extracts like PHYSTA from reputable sources to ensure safety & efficacy.

· Dosage & Cycling: Most studies use 200-400mg daily. Cycling (e.g., 8-12 weeks on, 1-2 weeks off) is often recommended, though not definitively proven necessary.

 

The Integrated Prevention Protocol with PHYSTA

 

If you choose to incorporate it:

 

1. Foundation First: Mediterranean diet, 150 mins/week aerobic exercise, 7-8 hours sleep, smoking cessation.

2. Medical Screening: Get your heart risk factors (lipids, HbA1c, BP) & testosterone/PSA levels checked to establish a baseline.

3. Add PHYSTA as an Adjunct: Consider 200-400mg daily of a standardized extract, with the understanding it's part of a holistic strategy.

4. Monitor: Re-check hormones and symptoms after 3 months. ED that persists demands a cardiac workup, regardless of supplement use.

 

Final Professional Comment: "PHYSTA Tongkat Ali represents a promising nutraceutical that targets the stress-hormone axis, which is a key but often overlooked piece of the male health puzzle. It fits best as a component in a proactive man's health regimen, aimed at optimizing vitality and resilience. However, the most potent 'medicine' for preventing the heart-ED-prostate cascade remains a heart-healthy lifestyle.

Think of PHYSTA as a sophisticated tuning tool for your body's systems, but the master mechanics are still diet, exercise & stress management."

NU-PREP

PHYSTA TONGKAT ALI

https://shop.biotropicsmalaysia.com/nu-prep-en/nu-prep-lelaki-60s-bm.html

Key Reference Snapshot:

 

· Talbott, S.M., et al. (2013). Eurycoma longifolia extract improves mood, testosterone, and cortisol. J Int Soc Sports Nutr.

· Henkel, R.R., et al. (2014). Tongkat Ali as a potential herbal supplement for erectile function. Evid Based Complement Alternat Med.

· Ismail, S.B., et al. (2012). Randomized clinical trial on the effects of Eurycoma longifolia on erectile function. Int J Impot Res.

 

Disclaimer: This information is for educational purposes. Consult your healthcare provider before starting any new supplement, especially if you have pre-existing conditions or are on medication.

WHEN TESTOSTERONE FELL, COVID-19 BECAME DEADLIER.

COVID-19. The Science Behind Male Vulnerability and the Emerging Role of PHYSTA® Tongkat Ali. 

When Testosterone Fell, COVID-19 Became Deadlier. A Scientific Story Connecting Hormones, Immunity & PHYSTA® Tongkat Ali.

PHYSTA® Tongkat Ali

During the peak of the COVID-19 pandemic, one observation consistently stood out across hospitals worldwide: men were dying at higher rates than women. For a long time, the reason was unclear.

 

That changed in July 2021, when Professor Andrea Salonia and his team from San Raffaele University Hospital, Milan, presented a landmark finding at the 36th Annual European Association of Urology Congress (EAU21).

Testosterone Test.

Study reveals that almost 90% of men have hypogonadism at the time of hospital admission for Covid-19.

What they discovered shocked even seasoned clinicians.

“I have never seen anything like this in my 25 years in the field.”

Prof. Andrea Salonia, EAU21, 2021

The Milan Discovery: Testosterone & COVID-19 Severity

In a cohort of 286 men hospitalized with COVID-19:

·       89.8% had low testosterone (hypogonadism) at admission

·       Only 14.9% of healthy controls showed low testosterone

The lower the testosterone level, the higher the risk of:

·       Severe disease

·       Intubation

·       Death

Ref : COVID-19 Is Associated With Low Testosterone in Men.

https://www.renalandurologynews.com/reports/male-hypogonadism-associated-with-sars-cov-2-severity-mortality-death/#:~:text=Low%20testosterone%20levels%20are%20highly,14.9%25)%20of%20health%20controls 

While the study did not definitively determine whether COVID-19 caused low testosterone or exploited it, the signal was unmistakable:

·       Low testosterone was strongly associated with poor COVID-19 outcomes and mortality in men. 

Men with low testosterone more likely to die from Covid-19.   

https://www.eurekalert.org/news-releases/707995#:~:text=Men%20with%20symptomatic%20Covid%2D19,cent%20of%20the%20healthy%20volunteers. 

This was not an isolated observation. Independent reports (including EurekAlert) reinforced the same conclusion:

·       men with low testosterone were significantly more likely to die from COVID-19.

·       Why Testosterone Matters in Viral Infections

Testosterone is not merely a “male hormone.” Scientifically, it plays critical roles in:

·       Immune regulation (T-cell balance, cytokine modulation)

·       Inflammation control (preventing cytokine overreaction)

·       Muscle, lung & metabolic resilience

·       Stress hormone (cortisol) suppression

When testosterone collapses:

Inflammation rises

Immune response becomes dysregulated

Recovery capacity weakens

COVID-19 did not just attack the lungs it exposed metabolic & hormonal vulnerabilities, particularly in aging or stressed men.

PHYSTA® Tongkat Ali: Where Hormonal Science Meets Antiviral Evidence

This is where PHYSTA®, the standardized water extract of Eurycoma longifolia (Tongkat Ali), becomes scientifically relevant not as speculation, but through published evidence.

1. Clinically Proven Testosterone Support

PHYSTA® is one of the most clinically studied Tongkat Ali extracts globally, with human trials demonstrating:

Restoration of testosterone levels in men with deficiency

Reduction of cortisol (stress hormone)

Improvement in energy, vitality & physiological resilience

These effects directly address the risk profile identified in severe COVID-19 patients.

2. Direct Antiviral Activity Against SARS-CoV-2 (In Vitro)

In May 2024, a peer-reviewed study published in the

Malaysian Journal of Pharmaceutical Sciences (Vol. 22, No. 1, pp. 77–86) reported:

“Antiviral activity of PHYSTA® standardized water extract of Eurycoma longifolia against SARS-CoV-2: An in vitro study”

PHYSTA® Tongkat Ali

Antiviral Activity of Physta®, Standardised Water Extract of Eurycoma longifolia against SARS-CoV-2: An in vitro Study

https://www.academia.edu/145229646/Antiviral_Activity_of_Physta_Standardised_Water_Extract_of_Eurycoma_longifolia_against_SARS_CoV_2_An_in_vitro_Study

Source: Universiti Sains Malaysia https://share.google/Ky3KJJ5TrNaso7M3u

Conducted by:

Biotropics Malaysia Berhad

Tropical Infectious Diseases Research & Education Centre (TIDREC)

University of Malaya

Key findings:

·       PHYSTA® inhibited SARS-CoV-2 replication in Vero cells

·       IC₅₀: 36.3 μg/mL (50% viral growth reduction)

·       No cytotoxicity at effective antiviral concentrations

·       Clear suppression of viral plaque formation within 72 hours

·       Favorable Selectivity Index (SI), indicating safety vs efficacy balance

Mechanistically, the antiviral activity was attributed to:

·       Eurycomanone

·       Saponins interfering with viral capsid protein synthesis

·       Immunomodulatory effects reducing excessive inflammation

3. Intellectual Property Protection

This discovery is further reinforced by a registered patent:

·       Patent No: PI2022005089

·       Title: Use of Eurycoma longifolia extract against Coronavirus

·       This reflects novelty, scientific merit & translational potential, not anecdotal use.

Connecting the Evidence Carefully & Scientifically

What the science allows us to say responsibly:

·       Severe COVID-19 is strongly associated with low testosterone in men

·       PHYSTA® is clinically proven to support testosterone

·       PHYSTA® has peer-reviewed in-vitro evidence showing inhibition of SARS-CoV-2

·       PHYSTA® demonstrates immune-modulating and anti-inflammatory properties

What science does not claim:

·       PHYSTA® is not positioned as a drug or a cure

·       In-vitro antiviral activity does not replace clinical COVID-19 treatment

 

Nu-Prep

Nu-Prep is powered exclusively by PHYSTA® a clinically studied, standardized Tongkat Ali extract.

The COVID-19 pandemic revealed a critical but under-recognized factor in men’s vulnerability: hormonal resilience, particularly testosterone status.

The convergence of:

·       European clinical observations (EAU21, Milan)

·       Hormonal biology

·       Peer-reviewed antiviral laboratory evidence

Clinically validated Tongkat Ali standardization (PHYSTA®)

places PHYSTA® in a unique scientific position not as speculation, but as a biologically plausible, evidence-supported natural intervention worthy of serious academic & clinical attention.

PHYSTA® is currently among the very few standardized herbal extracts with both:

·       Human clinical evidence for testosterone support &

·       Published in-vitro evidence against SARS-CoV-2

This does not close the chapter it opens a new one for future translational, clinical & preventive research at the intersection of men’s health, immunity & viral resilience.

nu-prep 

https://shop.biotropicsmalaysia.com/nu-prep-en/nu-prep-lelaki-60s-bm.html