"Beyond Conventional Medicine: PHYSTA® Tongkat Ali and the Future of Evidence-Based Preventive Health".

 “Blood Sugar - Regulated Nu-Prep Tongkat Ali. Better Treatment” plus clinical evidence & data on PHYSTA® Tongkat Ali water-soluble freeze-dried extract.  

 “Blood Sugar - Regulated Nu-Prep Tongkat Ali. Better Treatment”

Nu-Prep PHYSTA® Tongkat Ali

Note: https://www.youtube.com/watch?v=fZZdli0d1ZA video content focused on claims around blood sugar, testosterone & “better treatment than medicine”.

 

🌿 The Science Meets Modern Medicine: Tongkat Ali (Eurycoma longifolia)

Tongkat Ali, scientifically Eurycoma longifolia is a traditional Southeast Asian herbal root used for centuries for vitality, mood, libido & overall well-being. Modern medicine approaches such supplements through rigorous clinical trials, biomarkers & safety profiling rather than anecdote or folklore.

Wikipedia https://en.wikipedia.org/wiki/Eurycoma_longifolia?utm_source=chatgpt.com

 

But not all Tongkat Ali is the same & here’s where PHYSTA® stands apart.

🔬 What Makes PHYSTA® Special in Modern Clinical Terms

Standardized Water Soluble Freeze-Dried Extract

PHYSTA® is produced using a patented hot-water extraction & freeze-drying process designed to preserve the full spectrum of water-soluble bioactives especially eurycomanone, peptides, glycosaponins  antioxidants that are otherwise degraded by heat or alcohol extraction methods used in many supplements.

Nu Prep +1 https://nuprep.com.my/en/physta-r?utm_source=chatgpt.com

 

Quality & Regulatory Rigour

It is developed under strict Ministry of Health Malaysia, ISO, GMP & Halal certifications, with documented toxicology & quality studies validating consistency & safety.

Nu Prep https://nuprep.com.my/en/physta-r?utm_source=chatgpt.com

 

Clinical Research ‘Not Just Claims’

Unlike generic herb powders, PHYSTA® has multiple published human clinical studies that validate measurable biological effects a key requirement in evidence-based medicine.

PubMed +2 https://pubmed.ncbi.nlm.nih.gov/41283187/

 

 

🧠 What Western Medicine Actually Cares About

Physicians & scientists evaluate supplements based on:

Randomized Controlled Trials (RCTs) the gold standard in clinical research.

Validated Outcome Measures - testosterone levels, validated symptom scales, immune profiles, quality-of-life indices.

Safety & Tolerability - lab values, organ function tests, adverse event monitoring.

PHYSTA® has satisfied all three in multiple independent studies.

📊 Key Clinically Proven Effects of PHYSTA®

✅ 1. Testosterone & Quality of Life in Aging Men

A 12-week RCT showed that PHYSTA® significantly increased serum total testosterone & reduced ageing-male symptoms & fatigue compared to placebo. Higher doses showed early effects starting as soon as 2–4 weeks.

PubMed https://pubmed.ncbi.nlm.nih.gov/34262417/

 

✔ These are objective hormone & symptom improvements, not subjective marketing hype.

✅ 2. Sexual Function and Performance

In a double-blind, placebo-controlled trial, PHYSTA® combined with Polygonum minus significantly improved erectile function scores, erection hardness & male symptom scores compared to placebo.

PubMed https://pubmed.ncbi.nlm.nih.gov/24550993/

 

✔ These endpoints are validated by medicine as real functional outcomes not vague “vitality” claims.

✅ 3. Quality of Life in Women (Menopause)

A first-of-its-kind 12-week clinical trial in menopausal women found that PHYSTA® reduced total menopausal symptom scores by ~34%, with statistically significant improvements in physical & sexual domains.

PubMed +1 https://pubmed.ncbi.nlm.nih.gov/41283187/

 

✔ Shows gender-inclusive effects, widening clinical relevance beyond men.

 

✅ 4. Immune Modulation

A randomized study in adults showed PHYSTA® improved immunological vigor including increases in T-cell counts & immune grading after 4 weeks.

PubMed https://pubmed.ncbi.nlm.nih.gov/26816234/

 

✔ Immune enhancement is a measurable, clinically relevant endpoint especially in aging populations.

🧪 Modern Medicine’s Traditional Skepticism & How PHYSTA® Answers It

❓ Skepticism: “Supplements are unproven & unregulated.”

👉 Answer: PHYSTA® is one of the few extracts with multiple peer-reviewed human trials, standardized bioactive markers & regulated production standards matching what doctors expect from evidence-based therapeutics.

Nu Prep https://nuprep.com.my/en/physta-r?utm_source=chatgpt.com

 

“Herbal extracts can be adulterated or inconsistent.”

👉 Answer: Over 30 clinical & toxicology studies, authenticated raw materials & patented extraction eliminate guesswork, rejecting low-quality market products that sometimes contain contaminants or no active compounds at all. アスク薬品株式会社  

 

 

🧬 How PHYSTA® Works  ‘A Scientific Story’

Instead of focusing on symptoms alone, modern medicine asks:

What pathways are affected?

👉 PHYSTA® has shown:

·       Hormonal modulation (improved testosterone, balanced stress hormones)

·       Immune enhancement (increased immune grades and T-cells)

·       Improved cellular energy & physical function

·       Better mood & quality of life metrics

 

These are measurable, reproducible biological effects not simply placebo.

PubMed +1 https://pubmed.ncbi.nlm.nih.gov/34262417/

 

 

📖 A New Paradigm in Health

Imagine the standard medical care model:

·       Diagnostic → Prescription drug → Single effect

·       Often treats one symptom or one pathway.

·       Higher side-effect load.

Now contrast this with a clinically proven botanical like PHYSTA®:

·       🌿 Holistic modulation - not just one receptor or hormone but multiple pathways.

·       📈 Objective improvements - hormone balance, mood, endurance, immune resilience.

·       ⚖️ Safety profile - no significant labs changes, favorable tolerability.

PubMed https://pubmed.ncbi.nlm.nih.gov/34262417/

 

 

This is not a magic herb - it is an evidence-backed multi-endpoint botanical intervention. Western medicine rarely gives such credit unless it can see clear data & PHYSTA® delivers it.

🌟 PHYSTA® Tongkat Ali isn’t just another supplement - it is clinically validated, standardized, & measured against real medical endpoints. Unlike generic herbal extracts:

·       ✅ Evidence across age ranges (men & women)

·       ✅ Increases testosterone naturally

·       ✅ Enhances libido, strength, mood

·       ✅ Supports immunity

·       ✅ Demonstrates safety in controlled human trials

In the language of Western medicine, PHYSTA® is an adaptogenic botanical with measurable endocrine, immune & quality-of-life benefits, supported by clinical research a bridge between natural tradition & modern evidence.

PubMed +2 https://pubmed.ncbi.nlm.nih.gov/41283187/ 

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The Science of Kesum: Why This Humble Herb Is Making Researchers Excited.

The Green Gold of Southeast Asia: Unlocking the Secrets of Kesum

KESUM

BioKesum

If you’ve ever tasted the bright, peppery notes of kesum in a traditional Southeast Asian dish, you’ve experienced more than just flavor you’ve tasted a leaf packed with centuries of botanical mystery & modern scientific wonder. Often called Vietnamese coriander or laksa leaf, kesum (scientifically known as Polygonum minus) isn’t just a culinary star it’s a biochemical treasure chest. Let’s dive into the fascinating chemistry & chromatography that make this humble herb a rising "superfood" in the eyes of researchers worldwide.

🌿 A Leaf with a Legacy

Kesum belongs to the Polygonaceae family, a group of plants known for their medicinal and nutritional power. While it’s been a staple in kitchens across Malaysia, Thailand & Vietnam, scientists have only recently begun to decode its secrets. Early studies in the 1990s revealed that kesum leaves are rich in flavonoids natural compounds known for their antioxidant properties. Among them, trimethoxyflavone & tetramethoxyflavone were some of the first identified, hinting at the leaf’s hidden complexity.

🧪 The Biochemical Magic Within

KESUM

Biokesum

What makes kesum so special? It’s all in the molecules:

·       Quercetin & Quercitrin: These powerful flavonoids act as natural defenders against oxidative stress, supporting heart health & reducing inflammation.

Polygodial:

·       A unique sesquiterpene dialdehyde that gives kesum its signature pungent aroma & may hold antimicrobial properties.

Indole Alkaloids:

·       Recently discovered compounds like polygonumins A have sparked excitement for their potential neuroprotective effects meaning kesum could one day play a role in brain health & even Alzheimer’s research.

β-Sitosterol:

·       A phytosterol also found in P. hydropiper, known for supporting cholesterol balance & immune function.

 

Scientists have used advanced tools like 2D-IR spectroscopy & NMR to map these compounds, revealing kesum as more than just a garnish it’s a reservoir of bioactive potential.

📊 The Chromatography Chronicles.

KESUM

Biokesum

How do we "see" these invisible compounds? Through the art & science of chromatography.

In Thin Layer Chromatography (TLC), researchers can spot quercitrin like a hidden signature visible under UV light or as a yellow glow when treated with special reagents. When kesum extracts are separated this way, each spot tells a story of the leaf’s chemical diversity.

 

But the real magic happens in High Performance Liquid Chromatography (HPLC). Using a sophisticated C-18 column & a gradient of acetonitrile & formic acid, scientists have created chemical "fingerprints" of kesum extracts. The peaks in the chromatogram (like the one shown in Figure 3.6) represent different compounds eluting at precise times offering a clear, precise map of the leaf’s biochemical landscape.

🌱 Kesum in the Modern Research Spotlight 

KESUM

Biokesum

In the last decade, kesum has stepped into the scientific limelight:

·       It’s been reviewed as a potential superfood (Christopher et al., 2015).

·       Its extracts have been studied for anti-cancer, anti-aging & neuroprotective properties.

·       New extraction methods like liquid biphasic flotation are making it easier to isolate its precious compounds sustainably.

 

What’s next? Researchers are eyeing kesum not just as food, but as a source of natural therapeutics especially its indole alkaloids for brain health & its flavonoids for longevity.

 

✨ Why This Matters to You 

KESUM

Biokesum

Every time you sprinkle kesum into your soup or blend it into a paste, you’re not just adding flavor you’re inviting in nature’s own chemistry. From traditional medicine to modern labs, kesum is a beautiful example of how local plants can hold global promise.

 

So the next time you see those vibrant green leaves, remember: you’re looking at a leaf that’s been tasted, studied, and treasured from the kitchens of Southeast Asia to the laboratories of the future.

KESUM

Biokesum

References.

Based on findings from the National KESUM Initiative, Globinmed (2018), Pramita et al. (2013), Vikram et al. (2014), and ongoing research into Polygonum minus.

Love plants, science, and stories? Stay tuned for more deep dives into the hidden chemistry of everyday herbs. 🌿✨ 

KESUM

BIOKESUM

KESUM

BIOKESUM

KESUM

BIOKESUM

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The Clinically Proven Way to Naturally Support Healthy Platelet Levels.

 (The platelet-related findings from the Physta® studies).

The Physta® Breakthrough: Clinically Proven Support for Healthy Platelet Levels. 

Gold-standard clinical trials show Physta®, a patented Tongkat Ali extract, significantly increases platelet count in humans. Discover how it works with a clean safety profile, without affecting other blood markers.  

Clinically Proven.

Emerging clinical research reveals a significant & promising effect of a patented natural extract on a vital component of health: platelets. Physta®, the standardized, freeze-dried water-soluble root extract of Eurycoma longifolia Jack, has demonstrated a clear & measurable ability to support healthy platelet levels in humans, backed by rigorous safety data.

 The Clinical Evidence: A Significant Human Response.

A randomized, double-blind, placebo-controlled, parallel study on middle-aged humans investigated the immunomodulatory effects of Physta®. The results were clear:

·       Physta® supplementation produced a statistically significant increase in platelet count compared to the placebo group.

·       This finding is critical, as it demonstrates a direct, beneficial physiological response in humans using the gold standard of clinical trial design.

This human data confirms that Physta®'s bioactive compounds, preserved through its specialized water-based extraction & freeze-drying process, actively support the body's natural platelet regulation mechanisms.

Safety Confirmed: Specific Action Without Systemic Disruption.

Physta does not effect your blood status. Platelet- stabile blood count, healthy red blood cells, balanced white blood cells. Blood Health Unchanged.

The profound value of this finding is magnified by its exceptional safety profile. The research definitively shows that Physta®'s support for platelets is targeted and harmonious.

·       No Adverse Effect on Other Blood Parameters: Comprehensive blood panels conducted in clinical & pre-clinical studies confirm that while platelet levels were beneficially modulated, all other critical blood markers (e.g., red blood cells, white blood cells, liver enzymes, kidney function markers) remained within normal, healthy ranges. Physta® does not disrupt the broader hematological system.

·       Toxicology Safety Assurance: Long-term sub-acute animal studies (90-day repeated dose) further validated this safety. Detailed analysis showed no signs of toxicity & no negative impact on organ health or function, providing a strong foundation for its safe use in humans.

 

A Promising,  the evidence positions Physta® as a truly novel natural ingredient:

·       Proven Human Efficacy: It delivers a clinically significant increase in platelet count.

·       Uncompromising Safety: It achieves this without affecting other blood status indicators, demonstrating a precise & safe mode of action.

·       Ahead of Conventional Approaches: For individuals seeking natural support for healthy platelet levels, Physta® offers a research-backed, promising alternative that works with the body's physiology, validated by both human clinical trials & comprehensive safety science.

This combination of significant efficacy & documented safety establishes Physta® as a breakthrough in natural hematological support, offering a credible, science-based option derived from rigorous clinical investigation.

‘High-Confidence’. Lead with the Clinical Proof:

"A randomized, double-blind, placebo-controlled human study demonstrated that Physta® significantly increased platelet count."

"Critically, this benefit was achieved without altering other blood cell counts or chemistry, showing a targeted and safe action."  

 

 

(‘A high-confidence’, clinically-focused on the full blood count (FBC) / pathology profile).

A Clinically Validated Profile: Physta®'s Targeted Effect on Hematological Parameters

A comprehensive review of clinical & preclinical data reveals a specific & significant hematological effect of Physta® (standardized water-soluble root extract of Eurycoma longifolia Jack), with an otherwise clean & stable full blood count (FBC) & clinical chemistry profile.

 

1. Primary Efficacy: Significant Increase in Platelet Count.

 

The most notable & consistent finding across studies is a statistically significant increase in platelet count in human subjects following Physta® supplementation, as demonstrated in a randomized, double-blind, placebo-controlled (RDBPC) trial. This indicates a direct, bioactive influence on thrombopoiesis or platelet regulation, positioning Physta® as a natural agent of interest for supporting healthy platelet levels.

 

2. Safety & Specificity: A Clean Full Blood Count (FBC) and Biochemistry Panel.

Critically, this platelet-specific effect occurs without clinically significant alterations to other key hematological and biochemical markers. 

The clinical & toxicological evidence confirms: 

·       Erythrocyte Series Unaffected.

Parameters including Red Blood Cell (RBC) count, Hemoglobin (Hb), and Hematocrit (Hct) remained within normal physiological ranges, indicating no adverse effect on erythropoiesis or oxygen-carrying capacity.

 

·       Leukocyte Series Stable: Total White Blood Cell (WBC) count and differentials (neutrophils, lymphocytes, etc.) showed no significant deviations from baseline or placebo, confirming no undue stimulation or suppression of the immune system's cellular components.

 

·       Organ Function Preserved:

Comprehensive serum biochemistry panels including liver function tests (ALT, AST, ALP) and renal function markers (creatinine, urea) showed no signs of treatment-related toxicity or organ stress in both human and long-term (90-day) animal studies.

·       Lipid & Metabolic Profile: Key metabolic markers remained stable, further supporting systemic safety.

 

3. Integrated Conclusion from Clinical & Preclinical Pathology

The sub-acute (28-day and 90-day) toxicology studies in animal models provide essential confirmatory evidence. Detailed histopathological examination of major organs (liver, kidneys, spleen, heart) revealed no pathological lesions or treatment-related adverse findings, aligning perfectly with the clean serum biochemistry.

This concordance between human clinical pathology & preclinical toxicology validates the targeted nature of Physta®'s action.

Clinical Interpretation & Positioning

The collective pathology data presents a clear profile:

·       Efficacy: Physta® exhibits a significant, reproducible effect on increasing platelet count in humans.

 

·       Safety & Specificity: This effect is highly specific, occurring alongside a stable and unremarkable full blood count and clinical chemistry profile. There is no evidence of bone marrow suppression, dyscrasia, or organ toxicity.

·       Promising Profile: For professionals and individuals seeking natural support for platelet health, Physta® offers a clinically documented, targeted intervention with a safety profile that distinguishes it from pharmaceutical agents, which often carry broader hematological side effects.

 

In summary, Physta® demonstrates a unique, evidence-based combination of a significant desired effect on platelet parameters and an otherwise benign clinical pathology report, as validated by gold-standard human trials and GLP-compliant animal studies.

 

For Maximum Impact (e.g., in a Medical/Technical Brief):

· Use a Summary Table:

Parameter	Observed Effect with Physta®	Clinical Significance
Platelet Count	Significantly Increased	Primary efficacy endpoint; supports thrombopoiesis.
RBC, Hb, Hct	No Significant Change	No impact on erythropoiesis or anemia risk.
WBC & Differentials	No Significant Change	No immunostimulation or immunosuppression.
Liver Enzymes (ALT, AST)	No Significant Change	No evidence of hepatotoxicity.
Renal Markers (Creatinine)	No Significant Change	No evidence of nephrotoxicity.
Histopathology (Animal)	No Adverse Findings	Confirms organ-level safety.

Physta does not effect your blood status. Platelet- stabile blood count, healthy red blood cells, balanced white blood cells. Blood Health Unchanged.

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'Platelet'

Nu-Prep

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