Your Brain! Chief Executive Officer. CEO

 KESUM 'water soluble extract - freeze dried' clinically proven. 

Your Brain!  Chief Executive Officer. CEO

KESUM

KESUM

Central Nervous System Vital Signs (CNSVS) is a technology that administers neurocognitive & behavioral tests to objectively measure brain function performance ).

"In a clinical study, the supplement Biokesum demonstrated significant, measurable improvements in key areas of brain function, specifically Cognitive Flexibility and Executive Function. These results are not just based on how people felt, but on objective, computerized cognitive tests. The improvements were significantly greater than those seen in the placebo group, confirming the product's effectiveness."

( Let's break down what was tested and what the results mean for you ).

 

1.    Cognitive Flexibility: Your Brain's "Adaptability".

What it is:  This is your brain's ability to switch between different thoughts, tasks, or strategies. It's like mental agility, being able to "think on your feet" and see things from different perspectives. 

 

The Scientific Evidence: The group taking Biokesum started with a score of 6.43.  

 

·         After 12 weeks, their score skyrocketed to 33.56. This is a dramatic and statistically significant (\\**) improvement.

 

·         The placebo group also improved slightly (from 13.43 to 20.41), but the Biokesum group's improvement was far greater, and this difference between the groups was also statistically significant (#).

What this means for you: Taking Biokesum can significantly enhance your mental adaptability. You may find it easier to:

·         Switch between tasks at work or home without feeling stuck.

·         Find creative solutions to problems.

·         Adapt to unexpected changes in plans.

2.    Executive Function: Your Brain's "CEO" 

COGNITIVE performance - BDNF. 

KESUM

·   What it is: This is your brain's command and control center. It manages skills like planning, organizing, paying attention, remembering details, and getting things done. It's what you use to manage your time, cook a meal from a recipe, or organize your day.

 

The Scientific Evidence:

·         Biokesum group started with a score of 15.55.

·         After 12 weeks, their score more than doubled to 37.13. This is another powerful, statistically significant (\\) improvement.

·         The placebo group showed a very small, non-significant change, confirming that the powerful effect was due to the Biokesum supplement.

 

What this means for you:

Taking Biokesum can strengthen your brain's management system. You may experience better:

·         Planning & Organization: Feeling more on top of your schedule and responsibilities.

·         Focus & Attention: Staying on task with less mental distraction.

·         Working Memory: Holding information in your mind (like a phone number or a shopping list) while you use it.

 

Why You Can Be Confident in These Results.

i.             Objective Measurement: These results come from a standardized computerized neurocognitive test battery (CNSVS), not just personal surveys. This removes bias and measures actual performance.  

 

ii.            Placebo-Controlled: The study included a placebo group. The fact that Biokesum's results were significantly better than the placebo is the gold standard for proving a treatment's real effect.

 

iii.          Statistical Significance: The asterisks (\* and #) mean the improvements are very unlikely to be due to chance. The probability that these results are real is over 95% (P < 0.05). This is a high level of scientific confidence.

 

iv.          Clinically Relevant: The improvements weren't just small number changes; they were large and meaningful jumps in score, indicating a substantial boost in cognitive performance.

 

 

The evidence is clear. Biokesum provides a scientifically-validated boost to core cognitive functions that are critical for daily life specifically your mental adaptability (Cognitive Flexibility) and your brain's ability to manage complex tasks (Executive Function). If you are looking for a supplement to help you think more clearly, stay focused, and adapt more easily, this data provides a strong, confident reason to choose Biokesum.

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KESUM bottle display. 

Bioefficacy & Bioavailability.

Let’s unpack it clearly & then interpret it in simple, supplement-friendly terms so your team or public can easily understand.

Step 1. DATA.

Formulation	Nominal Dose	Bioavailability	Effective Absorbed Dose (mg)	Remark
Bioperine-based (Black Pepper Erxtract)	350 mg	55%	≈ 192-226 mg	Improve absorption via piperine effect (slows metabolism, enhances permeability)
Quercetin-based (bioKesum / Q-30G)	350 mg	148%	≈  518 mg (equivalent activity)	‘Super-absorbed’ due to active structure Q-3-0-glucuronide- natural metabolite from with sustained plasma retention.

(Q-30G  ≈  Quarcetin-3-0-glucuronide, the main active in KESUM / Polygonum minus).

BIOKESUM vs BIOPERINE

 

Step 2. What This Means Scientifically

Bioperine formulation works by enhancing absorption of other compounds (e.g., curcumin, resveratrol, or quercetin).

It makes the body absorb more of something that normally gets degraded quickly.

 

Quercetin-based formulation (BioKesum) does something even more interesting:

It is already in a bioactive, pre-converted form (Q-3OG) — meaning the body doesn’t have to metabolize it first.

Therefore, its bioavailability (148%) suggests it not only gets absorbed better but also stays longer in circulation, allowing higher biological impact per dose.

 

Step 3. Supplement Explanation

‘Supplement-market’ terms:

Aspect	Bioperine (55%)	BioKesum / Q-30G (148%)
Mechanism	Helps other ingredients absord better	Naturally high absorption and sustained action
Efficiency	You get half of what you take effectively	You get 1.5 X more than what you take effectively
Duration	Quick boost, shorter half-life	Longer-lasting, accumulative benefit
Example Effect	Helps nutrient uptake (support role)	Direct antioxidant, brain & circulation benefits ( active role )

 

In simple terms:

If both are taken at 350 mg:

Bioperine gives you about 226 mg worth of effective impact.

BioKesum gives you about 518 mg worth of effective impact more than double.

That’s a 2.3× improvement in real biological availability.

 

 

Step 4. Why This Matters Clinically

Q-3OG (from Kesum) doesn’t just circulate longer it reaches the brain, crossing the blood–brain barrier, linked to increases in BDNF (Brain-Derived Neurotrophic Factor).

Piperine (Bioperine) mainly works in the gut and liver to slow enzyme activity (CYP450). It’s beneficial but non-targeted.

 

Thus, BioKesum offers specific organ-targeted benefit, not just systemic absorption.

 

Step 5. BIOPERINE vs BIOKESUM (Q-30G)

From your data and known pharmacokinetic research:

·         Q-3OG (BioKesum) = significantly higher bioavailability, better systemic retention, and specific neurovascular activity.

·         Bioperine-based formulations are helpful for synergistic enhancement, but they remain “supportive,” not primary actives.

 

> “With BioKesum (Q-3OG), your body doesn’t just absorb more it uses it longer and more effectively, especially for brain and circulation health. Compared to Bioperine, it gives you over 2× more real action per capsule.”

 

COGNITIVE performance - BDNF. 

KESUM

COGNITIVE performance  BDNF.

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