Nu-Prep, perfect and official supplements 'extra push'

Nu-Prep, perfect and official supplements 'extra push'
Negative - Prohibited List. ADAMAS, New Delhi, India. NON-DRUG. Nu-Prep official supplement 'The National Sports Institute of Malaysia'

Saturday, 21 February 2026

Beyond 1822: Unearthing the 500-Year Legacy of Tongkat Ali and the Scientific Revolution for Women's Health.

A Heritage Feature on the Root of Tanah Melayu

Nu-Prep Wanita.

In the world of botanicals, few plants carry a name as misleading as Eurycoma longifolia Jack. The year 1822. A Scottish surgeon-botanist named William Jack, working for the East India Company in the humid landscapes of the Malay Archipelago, documented a slender, unassuming tree. He gave it a binomial name-Eurycoma longifolia- & appended his own surname, "Jack," to the discovery . https://en.wikipedia.org/wiki/Eurycoma_longifolia

 To the Western world, this was the "birth" of a new species. To Western herbalists, "Long Jack" became the curious root from the Far East.

 

But here is the truth that the dried herbariums of Europe could never capture: William Jack did not discover Tongkat Ali. He was simply centuries too late to the meeting.

 

For the healers, the warriors & the elders of Tanah Melayu, this "discovery" in 1822 is an oversight of the deepest kind. While Jack was carefully pressing leaves between parchment, the Orang Asli & the Malay people of the rainforest had already been harvesting this sacred root for generations. It was known as "Penawar Pahit" (The Bitter Remedy) and "Tongkat Ali" (Ali's Walking Stick) - named for its ability to give an old man the strength to stand tall again, & for women, a postpartum tonic to restore energy & vitality after childbirth .

https://en.wikipedia.org/wiki/Eurycoma_longifolia

 

We are not looking at a timeline of 200 years. We are looking at a heritage of 500 years or more of indigenous testimony, empirical observation & traditional use passed down through oral history. The West merely named it in 1822; the Malay world understood it centuries before.

Part 1: The Golden Age of Malacca - Where Tongkat Ali First Entered World Trade

To truly understand the depth of Tongkat Ali's heritage, we must look back to a time long before William Jack's birth - to the Golden Age of the Malacca Sultanate (1400–1511) .

 

Under its visionary sultans, Malacca rose from a humble fishing village to become the greatest emporium in all of Asia, a premier international entrepôt that controlled the vital trade routes between China, India, the Middle East & Africa . https://www.worldhistory.org/Portuguese_Malacca/

https://museum.um.edu.my/port-and-pottery-rediscovering-ancient-and-contemporary-ceramics-of-malacca

It was here, in the bustling port where the monsoon winds brought ships from across the known world, that the herbs & spices of the Malay Archipelago first entered global commerce.

 

Historical records from this period paint a vivid picture of Malacca's extraordinary reach. The Portuguese apothecary Tomé Pires, writing in his landmark Suma Oriental between 1512 & 1515, observed that "Whoever is lord of Malacca shall have his hands on the throat of Venice" . https://museum.um.edu.my/port-and-pottery-rediscovering-ancient-and-contemporary-ceramics-of-malacca

Such was the strategic importance of this tiny Malay kingdom.

What goods passed through this great emporium? The list reads like a treasure map of the East:

·       From the Spice Islands (Moluccas): Cloves, nutmeg & mace - commodities so precious they would later drive European exploration & conquest https://en.wikisource.org/wiki/Page:Journal_of_the_Straits_Branch_of_the_Royal_Asiatic_Society_(IA_journalofstra17181886roya).pdf/217

https://en.wikisource.org/w/index.php?title=Page:Cambridge_Modern_History_Volume_1.djvu/64&diff=next&oldid=1811309

 

·       From Borneo: Camphor, gold & fragrant woods . https://en.wikisource.org/wiki/Page:Journal_of_the_Straits_Branch_of_the_Royal_Asiatic_Society_(IA_journalofstra17181886roya).pdf/217

·       From Timor: Exquisite sandalwood https://en.wikisource.org/wiki/Page:Journal_of_the_Straits_Branch_of_the_Royal_Asiatic_Society_(IA_journalofstra17181886roya).pdf/217

 

https://en.wikisource.org/w/index.php?title=Page:Cambridge_Modern_History_Volume_1.djvu/64&diff=next&oldid=1811309

 

·       From Java and Sumatra: Pepper, rice & an array of spices https://icaption.perzim.gov.my/en/mar-the-trade-of-melaka-malacca/

 

·       From the Malay Peninsula itself: Ivory, rattan, tin & crucially - medicinal roots & forest products traded by the indigenous peoples such as the Jakun, Semang & Senoi  https://icaption.perzim.gov.my/en/mar-the-trade-of-melaka-malacca/

 

The Malay and foreign merchants carried out barter trade with these indigenous communities, exchanging pottery, utensils, salt & tobacco for the treasures of the rainforest - including resin, rattan, sandalwood & most significantly for our story, "medicinal roots" . https://icaption.perzim.gov.my/en/mar-the-trade-of-melaka-malacca/

These roots, carried down rivers from the interior to the coast, were the precursors to the standardized extracts we know today.

 

So extensive was this trade that 84 languages were once spoken in Malacca - a testament to the diversity of traders and workers the city attracted from across the globe .

https://icaption.perzim.gov.my/en/mar-the-trade-of-melaka-malacca/

Arab & Persian merchants sold perfumes, glassware, carpets & medicines. Chinese traders brought copper, tea, silk & porcelain. Indian merchants arrived with embroidery & textiles. And from Burma came precious stones & jade https://icaption.perzim.gov.my/en/mar-the-trade-of-melaka-malacca/

 

https://museum.um.edu.my/port-and-pottery-rediscovering-ancient-and-contemporary-ceramics-of-malacca

 

By the late 15th century, less than a hundred years after its foundation, the Sultanate of Malacca boasted an international community of 15,000 traders . https://www.worldhistory.org/Portuguese_Malacca/

The annual volume of trade reached an astonishing 2 million cruzados, with 50,000 cruzados flowing into the Malacca treasury through taxation. https://icaption.perzim.gov.my/en/mar-the-trade-of-melaka-malacca/

 

This was the world in which Tongkat Ali first entered the stream of international commerce. Long before any European botanist placed it under a microscope, the bitter root was already being traded, valued & used by the diverse peoples who made Malacca their home. It was part of a sophisticated network of traditional medicine that served everyone from royalty to commoners, from Malay warriors to Chinese merchants, from Arab traders to indigenous healers.

 

The maritime laws of Malacca, promulgated to regulate this vast trading system, ensured that these precious goods moved safely through waters patrolled by the Orang Laut (sea people) under the command of the Laksamana (admiral) . https://icaption.perzim.gov.my/en/mar-the-trade-of-melaka-malacca/

The Sultans took stern action against pirates who threatened this trade, understanding that the kingdom's prosperity depended on the free flow of goods - including the medicinal roots that came from deep within the rainforest https://icaption.perzim.gov.my/en/mar-the-trade-of-melaka-malacca

 

When the Portuguese finally conquered Malacca in 1511, they stepped into a world where this trade was already ancient. They did not create it; they simply became its newest participants https://www.worldhistory.org/Portuguese_Malacca/

 

Part 2: The Dishonesty of 1822 - A Heritage Older Than Colonial Records

 

Against this backdrop of centuries of trade & traditional use, William Jack's 1822 "discovery" appears in its true light. He observed the plant, but he failed to observe the people. He saw the root, but he did not see the centuries of wisdom attached to it.

 

Long before the British established their presence, the indigenous communities of Malaysia had integrated Tongkat Ali into the fabric of life. They consumed decoctions of the bitter root not just for virility, but for a concept the West is only now beginning to understand: adaptogens. They used it to cool fevers, to heal dysentery & as a vital energy tonic for women after the immense physical stress of childbirth .

https://en.wikipedia.org/wiki/Eurycoma_longifolia

https://www.360doc.cn/article/1511603_936795605.html

 

The oral history of Tanah Melayu speaks of royal courts where the root was reserved for the Hulubalang (warriors) before battle & for aging Sultans to ensure the continuation of their lineage. Legend tells of a 90-year-old elder named Ali who, after becoming lost in the forest, consumed the root & found the strength not only to survive but to return to his people rejuvenated - giving the herb its enduring name, "Ali's Walking Stick" https://www.360doc.cn/article/1511603_936795605.html

 

Later, during the resistance against British colonial rule, Malay fighters in the jungle used Tongkat Ali as a medical staple, relying on its properties to maintain their health & stamina while evading capture . The famed Malay warrior Mat Kilau, who reportedly lived to the age of 124, was said to have attributed his longevity & vitality to this sacred root https://www.360doc.cn/article/1511603_936795605.html

 

To claim that 1822 is the starting point of Tongkat Ali's story is to erase all of this - to dismiss the intelligence of the Malay civilization that built Malacca into a global trading power, that developed sophisticated systems of traditional medicine & that sustained the health of its people for generations through the wisdom of the rainforest.

 

The reality is this: when William Jack arrived, Tongkat Ali was already an ancient healer. He gave it a Latin name; we gave it a soul.

Part 3: The Gold Standard – A Body of Evidence Unmatched in the Herbal World

 

If heritage gives Tongkat Ali its soul, then science gives it its voice. And that voice is now the loudest in the room. When we speak of evidence, we must speak of the gold standard: randomized, double-blind, placebo-controlled clinical trials published in peer-reviewed medical journals.

 

Here is the reality that sets Tongkat Ali apart from every other herb on the planet. The development of Physta®, the world's first patented standardized water extract of Tongkat Ali, was a collaboration between Malaysian ingenuity & the Massachusetts Institute of Technology (MIT). This wasn't just about creating a supplement; it was about creating a pharmaceutical-grade ingredient that could stand up to the scrutiny of the world's toughest regulators.

 

The numbers speak for themselves, and they are undeniable:

·       14 Clinical Studies on Physta® by Biotropics Malaysia: The primary custodian of this science, Biotropics, has conducted 14 clinical studies on its Physta® extract, establishing a foundation of safety & efficacy that is rare in the botanical world.

 

·       26 Published Clinical Studies on Physta® Worldwide: When you look across the global research landscape, the Physta® extract has been the subject of 26 human clinical studies. This is an unprecedented volume of research for a single herbal extract.  

 

 

·       12 Published Clinical Studies by Biotropics: Of those, 12 studies have been published by Biotropics in reputable, peer-reviewed scientific journals, contributing directly to the global body of medical knowledge.

 

To put this in perspective, no other Malaysian herb - & very few herbs globally - can boast this level of scientific validation. This isn't traditional medicine trying to prove itself; this is modern science validating ancient wisdom.

 

Part 4: The Paradigm Shift - From Male Tonic to Female Fountain of Youth

 

For much of the 20th and 21st centuries, Big Pharma viewed Tongkat Ali through a narrow lens: a natural testosterone booster for men. The race was on to create testosterone replacement therapies, yet they consistently failed to produce a safe, effective & natural regulator for female hormones - specifically for the 1.2 billion women globally entering the perimenopausal & postmenopausal transition phase.

 

The clinical research, however, has revealed a stunning truth that the Malay healers perhaps knew intuitively: You cannot fix a woman's engine by only looking at the oil.

The Science: Testosterone is the Mother of Estrogen

The human body operates on a principle of hormonal conversion. In women, the ovaries & adrenal glands produce testosterone. This testosterone is then converted by the enzyme aromatase into estradiol, the primary form of estrogen.

 

When a woman enters menopause, estrogen production from the ovaries plummets. The current pharmaceutical solution - Synthetic Hormone Replacement Therapy (HRT) - has been linked to increased risks of cancer, cardiovascular disease & stroke.

 

But what if, instead of giving a woman estrogen (which tells the body to stop making its own), we gave her the tools to build her own?

 

This is where the heritage of Tanah Melayu collides with modern endocrinology.

 

By boosting a woman's natural testosterone levels safely with Tongkat Ali, the body retains the raw material necessary to convert into estrogen. You are not forcing the body into submission; you are rekindling the body's natural factory.

 

The Evidence in Women

 

A landmark 2025 study published in the World Journal of Clinical Cases investigated the effect of Eurycoma longifolia (Physta®) on 138 menopausal women aged 40-55. This randomized, double-blind, placebo-controlled trial delivered stunning results:

 

·       Women taking 100 mg of Physta® daily for 12 weeks saw a 33.9% reduction in total menopausal symptoms, as measured by the MENQOL (Menopause-Specific Quality of Life) questionnaire.

 

·       The improvements were most dramatic in the physical domain (a 36.4% reduction in symptoms like fatigue & joint pain) & the sexual domain (a 36.3% reduction in symptoms like vaginal dryness & decreased libido).

 

·       Total mood disturbance declined by 38.6% in the Physta® group, compared to just 30.1% in the placebo group, indicating a powerful effect on the emotional turmoil of menopause.

 

Crucially, the study confirmed the safety of this approach. There were no significant changes in reproductive hormone profiles, meaning Physta® wasn't adding hormones; it was supporting the body's own regulatory systems.

 

Part 5: The Japanese Discovery  - Turning Back the Biological Clock by 3.5 Years

 

If there is one piece of evidence that should silence every critic & excite every investor, it is the groundbreaking research from Japan on Physta®.

We must look closely at the study that changed the game:

 

Source: Phytotherapy Research, April 2016.

Title: Immunomodulation in Middle-Aged Humans Via the Ingestion of Physta® Standardized Root Water Extract of Eurycoma longifolia Jack.

Author: Annie George et al.

 

This randomized, double-blind, placebo-controlled study - the gold standard of science - investigated the biological impact of Tongkat Ali on 84 middle-aged men & women (40-59 years).

 

The "3.5 Years Younger" Claim

The study didn't just ask participants if they "felt" better. It measured physiological markers of aging. The research demonstrated that Tongkat Ali supplementation significantly improved the Scoring of Immunological Vigor (SIV) . Participants in the Tongkat Ali group showed higher numbers of total T-cells, naïve T-cells, and CD4+ T-cells - all critical components of a strong, youthful immune system.

 

Claims such as "biological age younger by 3.5 years" are supported by looking at:

 

·       Telomere Dynamics: The caps on our chromosomes that shorten as we age.

 

·       Immune Cell Profiling: Increased production of naïve T-cells, which are essential for fighting new infections & are typically depleted with age.

 

·       Inflammatory Markers: Drastically reducing cytokines that cause "inflammaging."

 

·       Hormone Panels: Restoring DHEA & free testosterone to optimal mid-life levels.

 

The Physta® technology proved that the internal body of a 50-year-old woman could function with the vitality of a 46.5-year-old.

 

What does this mean for women?

It means waking up with energy instead of fatigue. It means a strengthened immune system that doesn't collapse after a long week. It means keeping the skin elastic, the mind sharp, and the spirit young. It is not about living forever; it is about living younger for longer.

 

Part 6: The Global Context – Is There Any Herb That Competes?

In the vast pharmacopeia of the world, from the Andes to the Himalayas, many herbs claim to enhance vitality. Ashwagandha (India) is a powerful adaptogen for stress. Maca (Peru) is renowned for libido & energy. Ginseng (Korea/China) is a classic tonic for stamina.

 

However, based on published, peer-reviewed medical journal data regarding hormonal modulation in aging females, where does Tongkat Ali stand?

 

·       Ashwagandha: Excellent for cortisol reduction (stress), but its direct impact on the testosterone-to-estrogen conversion pathway in post-menopausal women is not as clinically profound as Tongkat Ali.

·       Maca: Often called "Peruvian Ginseng," it balances hormones but works through the hypothalamus & pituitary gland indirectly.

·       Physta® (Eurycoma longifolia): Currently stands alone in having 26 human clinical trials specifically demonstrating its effects, with multiple RCTs focusing on immunomodulation, stress reduction & quality-of-life improvements in both men & women.

 

The 2022 systematic review & meta-analysis published in Medicina confirmed that Tongkat Ali significantly improves total testosterone levels, particularly in individuals with low baseline levels. While some critiques note that many studies are funded by the manufacturer, this is also a testament to the commitment to rigorous science that is virtually unheard of in the herbal industry.

 

No other herb from any other continent has penetrated the Western pharmaceutical consciousness for female health quite like Tongkat Ali is doing now.

 

Part 7: The Future - Closing the Women's Health Gap

As we look to 2025 & beyond, the focus is sharpening. Biotropics Malaysia has announced the official launch of Physta® for Women's Health in 2025, a dedicated initiative to address the decades of under-diagnosis & under-representation of women in healthcare research.

 

The science is now clear: Tongkat Ali is not just a man's herb. It is a woman's ally in the battle against time.

 

Conservation & Sustainability

This heritage comes with responsibility. Because Tongkat Ali is harvested for its roots, the entire plant must be uprooted, raising serious sustainability concerns . The Malaysian government has responded by banning the export of raw Tongkat Ali roots, ensuring that value-added processing occurs within the country . https://en.wikipedia.org/wiki/Eurycoma_longifolia

 

The plant is listed as a priority medicinal species for conservation & harvesting of wild trees is restricted under Act 686 on International Trade in Endangered Species . https://en.wikipedia.org/wiki/Eurycoma_longifolia

 

In 2016, the Malaysian Minister of Agriculture warned that the species could face extinction within twenty years if cultivation & replanting efforts are not accelerated . https://en.wikipedia.org/wiki/Eurycoma_longifolia

Yet paradoxically, this conservation challenge also presents an opportunity. The 2010 Economic Transformation Programme identified Tongkat Ali as one of the top five herbs to be developed on a large scale, with government grants supporting commercial cultivation through cluster farms & agronomy research https://en.wikipedia.org/wiki/Eurycoma_longifolia

 

1. Supply is Constrained: Wild harvesting is restricted. Cultivation is mandatory to protect the species.

2. Demand is Exploding: Aging populations in Japan, the US, and Europe are desperate for non-pharmaceutical solutions to menopause.

3. Technology is the Moat: The "winner" in this space isn't the farmer; it's the company holding the patents for standardized extracts like Physta®, which guarantee the potency & safety that global regulators demand. It is self-affirmed GRAS in the US, compliant with GMP, HACCP & ISO standards & certified Halal by JAKIM & Kosher by Badatz.

 

The Return to the Root

 

From the bustling port of 15th-century Malacca, where 84 languages mingled & medicinal roots from the rainforest entered global trade for the first time, to the laboratories of modern Japan where scientists measure immunological vigor & biological age - the journey of Tongkat Ali has come full circle.

 

William Jack is a footnote in history. He gave us a name, but the Malay healers & the traders of the Malacca Sultanate gave us the knowledge.

 

The data is undeniable: 14 studies from Biotropics, 26 clinical studies worldwide, and 12 peer-reviewed publications form a mountain of evidence that cannot be ignored. Tongkat Ali, the bitter root of the Malaysian rainforest that was already ancient when the first European ships arrived at Malacca's harbor, can rekindle the hormonal fire in a menopausal woman, boost her immune system & turn back her biological clock by 3.5 years.

 

The pharmaceutical race to treat women is over. They didn't win it in a lab. The answer was always here, in the soil of Tanah Melayu, traded through the greatest emporium Asia had ever known, waiting for science to catch up to wisdom.

 

Science First, Everything Follows. And the science leads us right back to the roots of Malaysia.

 

References

 

1. Biotropics Malaysia. (2025). Physta® Technology: Things You Should Know About The World's First Patented Tongkat Ali Extract.

2. Akarali. (2023). Physta® Tongkat Ali Clinical Studies.

3. Examine.com. (2025). Does tongkat ali increase testosterone levels?

4. Muniandy, S., et al. (2025). Effect of Eurycoma longifolia water extract (Physta®) on menopausal quality of life and mood states. World Journal of Clinical Cases, 13(31): 109113.

5. The Manila Times. (2024). Closing the Women's Health Gap - Highlights of Biotropics Malaysia clinical study.

6. George, A., et al. (2016). Immunomodulation in Middle-Aged Humans Via the Ingestion of Physta® Standardized Root Water Extract of Eurycoma longifolia Jack. Phytotherapy Research.

7. Kotirum, S., et al. (2015). Efficacy of Tongkat Ali (Eurycoma longifolia) on erectile function improvement: systematic review and meta-analysis.

8. Thu, H. E., et al. (2022). Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials.

9. Wikipedia Contributors. (2025). Eurycoma longifolia. Wikipedia.

https://en.wikipedia.org/wiki/Eurycoma_longifolia

 

10. World History Encyclopedia. (2021). Portuguese Malacca.

https://www.worldhistory.org/Portuguese_Malacca/

 

11. Perbadanan Muzium Melaka. The Trade of Melaka (Malacca).

https://icaption.perzim.gov.my/en/mar-the-trade-of-melaka-malacca/

 

12. Universiti Malaya. (2023). Port and Pottery Rediscovering Ancient and Contemporary Ceramics of Malacca.

https://museum.um.edu.my/port-and-pottery-rediscovering-ancient-and-contemporary-ceramics-of-malacca

 

13. Wikisource. (1886). Journal of the Straits Branch of the Royal Asiatic Society.

https://en.wikisource.org/wiki/Page:Journal_of_the_Straits_Branch_of_the_Royal_Asiatic_Society_(IA_journalofstra17181886roya).pdf/217

 

14. Wikisource. (2013). Cambridge Modern History Volume 1.

https://en.wikisource.org/w/index.php?title=Page:Cambridge_Modern_History_Volume_1.djvu/64&diff=next&oldid=1811309

 

15. 360Doc. (2020). 一分钟让您了解马来西亚特产"东革阿里". https://www.360doc.cn/article/1511603_936795605.html

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